{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:38:48Z","timestamp":1787611128995,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>OLT1177\u2122 (Dapansutrile) is a newly developed drug that specifically inhibits the NLRP3 inflammasome and is safe in humans. Initially formulated as a topical treatment for degenerative arthritis, it has since been developed into an oral form. Both topical gel and oral capsules have demonstrated that OLT1177 is safe and well\u2010tolerated in humans, with a satisfactory safety profile and efficacy in reducing target joint pain. Inflammasomes are cytoplasmic proteins that activate caspase\u20101 in response to microbial invasion and damage signals. The NLRP3 inflammasome is one of the NOD\u2010like receptor family members and is widely studied and activated by various stimuli. NLRP3 inflammasome activation is regulated through a two\u2010step process, with priming at transcriptional and posttranslational levels and assembly by multiple pathways. The NLRP3 inflammasome, which activates inflammation\u2010related diseases, is primarily activated through K+ efflux, mitochondrial dysfunction, and lysosomal rupture. However, its regulation in humans remains unclear. NLRP3 inflammasome composition, downstream pathways, and inhibitor development offer the potential for treating inflammation\u2010related diseases. Several inhibitors have emerged and are currently in clinical trials, with over 10 having completed trials and recruiting participants.<\/jats:p>","DOI":"10.1002\/jbt.70790","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:19:10Z","timestamp":1775287150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Narrative Review of the Pharmacological Potential of Dapansutrile, a Selective NLRP3 Inflammasome Inhibitor"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-1774","authenticated-orcid":false,"given":"Rehab S.","family":"Abdelrahman","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University Madinah Saudi Arabia"},{"name":"Health and Life Research Center Taibah University Madinah Saudi Arabia"},{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2813-245X","authenticated-orcid":false,"given":"Samar","family":"Miski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0941-9696","authenticated-orcid":false,"given":"Tahani","family":"Saeedi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University Madinah Saudi Arabia"},{"name":"Health and Life Research Center Taibah University Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00670-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016287"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.08.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2019.11.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124223"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115750"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200123093544"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111822"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2018.11.013"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1413-8"},{"issue":"30","key":"e_1_2_12_13_1","first-page":"7334","article-title":"Tan RPJJoMCB","volume":"12","author":"Chan A. 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