{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:42:30Z","timestamp":1787316150349,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Male infertility represents one of the most troublesome of cyclophosphamide (CYP), a frequent chemotherapeutic agent, restricting its clinical usage. Diacerein (DIA), an anthraquinone derivative inhibiting interleukin\u20101 beta (IL\u20101\u03b2), is often applied as an anti\u2010inflammatory agent in managing osteoarthritis with antioxidant and anti\u2010inflammatory potential, making it a hopeful therapeutic strategy for testicular dysfunction. This study was conducted to investigate the probable safeguarding afforded by DIA on CYP\u2010induced testicular injury in male rats, pointing to the possible mechanisms involved in DIA protection. In a 14\u2010day experiment, 32 adult male rats were involved in this study and distributed into four groups: control, DIA, CYP, and CYP\u2009+\u2009DIA groups. Diacerein opposed testicular damage caused by CYP, which is demonstrated by the improved histological construction and amelioration of the abnormalities in sperm indices and testosterone concentration. DIA enhanced the activity of antioxidant enzyme, superoxide dismutase, and reduced glutathione levels alongside minimized malondialdehyde and total nitrite content in the testes of CYP\u2010challenged rats. In testicular tissues, DIA pretreatment counteracted the up\u2010regulation in the toll\u2010like receptor 4\/nuclear factor\u2010kappa B\/IL\u20101\u03b2 pathway\u2010mediated inflammation. Moreover, DIA abrogated CYP\u2010provoked apoptosis, as evident by down\u2010regulated cleaved\u2010caspase\u20103 expression. In summary, the results of this investigation reported that DIA's antioxidant, anti\u2010inflammatory, and antiapoptotic impact mediated its protective influence against CYP\u2010induced male organ toxicity.<\/jats:p>","DOI":"10.1002\/jbt.70795","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:12:02Z","timestamp":1777317122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insights Into the Ameliorative Effect of Diacerein on Cyclophosphamide\u2010Induced Testicular Toxicity: Targeting TLR4\/NF\u2010\u03baB\/IL\u20101\u03b2 Pathway"],"prefix":"10.1002","volume":"40","author":[{"given":"Ayaat M.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Assiut Urology Hospital Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7933-2344","authenticated-orcid":false,"given":"Heba A.","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6907-4441","authenticated-orcid":false,"given":"Gehan H.","family":"Heeba","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","first-page":"647","article-title":"Preventive Effects of Quercetin Against Inflammation and Apoptosis in Cyclophosphamide\u2010Induced Testicular Damage","volume":"27","author":"Uzun\u2010Goren D.","year":"2024","journal-title":"Iranian Journal of Basic Medical Sciences"},{"issue":"2","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3390\/ph16020301","article-title":"Hesperidin Mitigates Cyclophosphamide\u2010Induced Testicular Dysfunction via Altering the Hypothalamic Pituitary Gonadal Axis and Testicular Steroidogenesis, Inflammation, and Apoptosis in Male Rats","volume":"16","author":"Khamis T.","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"1","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep14043","article-title":"Role of the Katp Channel in the Protective Effect of Nicorandil on Cyclophosphamide\u2010Induced Lung and Testicular Toxicity in Rats","volume":"5","author":"Ahmed L. 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