{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:28:54Z","timestamp":1786566534239,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatotoxicity, principally driven by oxidative stress and inflammation, is a notable adverse effect of cytarabine, a chemotherapeutic drug extensively utilized in cancer therapy. This research examines the hepatoprotective properties of the natural monoterpenoid geraniol (GNL) in a murine model of cytarabine\u2010induced hepatic injury, emphasizing its influence on oxidative stress, inflammation, and critical signaling pathways like PI3K\/AKT and NF\u2010\u03baB. The animals were categorized into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096). Groups II and III were administered cytarabine at a dosage of 0.3\u2009mg\/kg (i.p.) for a duration of 7 days. Group III received a pre\u2010treatment of GNL (20\u2009mg\/kg) via intraperitoneal injection for 7 days prior to administration of cytarabine. Group IV was administered GNL only at a dosage of 20\u2009mg\/kg for 7 days. Group I served as a control. Cytarabine administration led to increased liver damage markers, including elevated blood ALT and AST levels, alongside heightened oxidative stress as seen by increased malondialdehyde (MDA) levels and diminished antioxidant enzyme activity (SOD and CAT). Moreover, cytarabine\u2010induced inflammation was marked by elevated levels of pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2) and the activation of the NF\u2010\u03baB signaling pathway, evidenced by enhanced nuclear translocation of p65. GNL therapy markedly alleviated these effects, lowering blood ALT and AST levels while reestablishing antioxidant equilibrium by diminishing MDA levels and augmenting SOD and CAT activity. Histopathological examination demonstrated significant improvement in liver tissue structure, characterized by reduced hepatocyte degradation and inflammatory infiltration. GNL suppressed NF\u2010\u03baB activation while promoting PI3K\/AKT signaling, resulting in decreased pro\u2010inflammatory cytokines and less liver damage. These findings underscore the potential of GNL as a hepatoprotective drug against cytarabine\u2010induced hepatotoxicity, mediated by its antioxidant and anti\u2010inflammatory effects through modulation of the PI3K\/AKT and NF\u2010\u03baB pathways. Future research should investigate its therapeutic potential in alleviating chemotherapy\u2010induced liver damage.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70820","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:16:51Z","timestamp":1774336611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Geraniol Mitigates Cytarabine\u2010Induced Hepatotoxicity in Mice via PI3K\/AKT\u2010Mediated NRF2 Activation"],"prefix":"10.1002","volume":"40","author":[{"given":"Rebai Ben","family":"Ammar","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, College of Science King Faisal University Al\u2010Ahsa Saudi Arabia"},{"name":"Laboratory of Aromatic and Medicinal Plants, Center of Biotechnology of Borj\u2010Cedria Technopole of Borj\u2010Cedria Hammam\u2010Lif Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-4388","authenticated-orcid":false,"given":"Peramaiyan","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Science King Faisal University Al\u2010Ahsa Saudi Arabia"},{"name":"COMManD, Department of Biochemistry, Saveetha Dental College &amp; Hospitals, Saveetha Institute of Medical and Technical Sciences Velappanchavadi Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Abdulaziz","family":"Alamer","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Science King Faisal University Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duaa","family":"Althumairy","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Science King Faisal University Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8048-7378","authenticated-orcid":false,"given":"Mayyadah Abdullah","family":"Alkuwayti","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Science King Faisal University Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13050966"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2016.1190831"},{"key":"e_1_2_10_4_1","unstructured":"H.Ba\u011fandY. 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