{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:11:27Z","timestamp":1778245887855,"version":"3.51.4"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Generation of some new complexes of dimethyltin(IV) of sterically congested 4\u2010acylated amphiphilic edaravone having the general formula Me\n 2<\/jats:sub>\n SnLL\u2032 and Me\n 2<\/jats:sub>\n Sn(L\u2032)\n 2<\/jats:sub>\n (where LH=\n \n , R\u2009=\u2009\u2500CH\n 3<\/jats:sub>\n , L\n (1)<\/jats:sub>\n H; R\u2009=\u2009\u2500CH\n 2<\/jats:sub>\n CH\n 3<\/jats:sub>\n , L\n (2)<\/jats:sub>\n H; R\u2009=\u2009\u2500C\n 6<\/jats:sub>\n H\n 5<\/jats:sub>\n , L\n (3)<\/jats:sub>\n H; R\u2009=\u2009p\u2010ClC\n 6<\/jats:sub>\n H\n 4<\/jats:sub>\n \u2500, L\n (4)<\/jats:sub>\n H and L\u2032 H=\n \n R\u2032= p\u2010OCH\n 3<\/jats:sub>\n C\n 6<\/jats:sub>\n H\n 4<\/jats:sub>\n \u2500, L\u2032\n (1)<\/jats:sub>\n H; R\u2032= p\u2010CH\n 3<\/jats:sub>\n C\n 6<\/jats:sub>\n H\n 4<\/jats:sub>\n \u2500, L\u2032\n (2)<\/jats:sub>\n H) has been accomplished. The newly generated complexes were characterized with the help of spectroscopic analysis [IR and NMR (\n 1<\/jats:sup>\n H,\n 13<\/jats:sup>\n C and\n 119<\/jats:sup>\n Sn)] assisted by DFT and HRMS studies.\n 119<\/jats:sup>\n Sn NMR spectral data of some of these complexes revealed the existence of hexa\u2010coordinated tin centres in these complexes. HRMS studies of some of the representative complexes suggested monomeric nature of these complexes. The optimized molecular structures and optimized energies of one representative ligand L\u2032\n (1)<\/jats:sub>\n H and the corresponding complexes, Me\n 2<\/jats:sub>\n SnL\n (4)<\/jats:sub>\n L\u2032\n (1)<\/jats:sub>\n (Complex 4) and Me\n 2<\/jats:sub>\n Sn(L\u2032\n (1)<\/jats:sub>\n )\n 2<\/jats:sub>\n (Complex 9) were calculated using DFT\u2010B3LYP functional in Spartan 20 computational modelling software. Some representative ligands and their corresponding dimethyltin(IV) complexes were tested for their antioxidant activity by 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl (DPPH) assay. Mechanistic insights into SET versus HAT pathways for antioxidant activity of dimethyltin(IV) formulations of 4\u2010acylated edaravone derivatives have also been studied.\n <\/jats:p>","DOI":"10.1002\/jbt.70832","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:28:42Z","timestamp":1778243322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Promising Synthetic Antioxidants of Dimethyltin(IV) Formulations Derived From 4\u2010Acylated Edaravone: Design, DFT Assisted Optimized Molecular Structure and Mechanistic Insights into SET Versus HAT Pathways for Antioxidant Activity"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3555-8576","authenticated-orcid":false,"given":"Anita","family":"Kumawat","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Rajasthan Jaipur Rajasthan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-3918","authenticated-orcid":false,"given":"Komal","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Rajasthan Jaipur Rajasthan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Rajasthan Jaipur Rajasthan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7624-590X","authenticated-orcid":false,"given":"Asha","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Rajasthan Jaipur Rajasthan India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23276","article-title":"Deciphering Mechanistic Implications of Antimicrobial and Antioxidant Potentials of Certain New Dibutyltin (IV) Formulations as Possible Therapeutic Options Based on DFT and Hybrid Materials Paradigm","volume":"37","author":"Soni K.","year":"2023","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/10426507.2016.1266356","article-title":"Generation, Spectroscopic Characterization and Antioxidant Activity of Tetracoordinate and Hexacoordinate Complexes of Diethylgermanium(IV) of Relatively Sterically Undemanding N\u2010Protected Amino Acids and Sterically Demanding Heterocyclic \u03b2\u2010diketones Containing Radical Sensitive Ge\u2010O Bond","volume":"192","author":"Maheshwari K.","year":"2017","journal-title":"Phosphorus, Sulfur and Silicon and the Related Elements"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3390\/molecules26051205","article-title":"Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions With Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities","volume":"26","author":"Adeleke A. 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