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Interferon\u2010gamma (IFN\u2010\u03b3), a proinflammatory cytokine released by activated T lymphocytes and natural killer cells, disrupts endothelial junctional integrity, leading to barrier dysfunction. Octreotide (OCT), a synthetic somatostatin analog (SSA), is used to suppress excessive growth hormone secretion and inhibits tumor growth. The present study investigates the potential anti\u2010inflammatory and cytoprotective properties of OCT in IFN\u2010\u03b3\u2010induced endothelial injury. Our observations suggest that OCT suppresses IFN\u2010\u03b3\u2010induced activation of cofilin, MLC2, JAK2, STAT1, STAT3, and P38; as well as endothelial hyperpermeability and ROS generation. 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