{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:28:54Z","timestamp":1786566534414,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Insulin Resistance (IR) is usually associated with elevated glucose levels and hyperinsulinemia. Elevated insulin levels during IR contribute to prostate enlargement and can lead to the condition of Benign Prostatic Hyperplasia (BPH). This study investigated the effects of capsaicin, a bioactive compound derived from chilli peppers, on IR\u2010induced prostatic hyperplasia. High\u2010fat diet (HFD) combined with streptozotocin (STZ) was used to induce IR in rats. Rats subjected to HFD\u2009+\u2009STZ exhibited elevated fasting blood glucose, insulin levels and an increased Prostate weight, confirming IR\u2010induced prostate enlargement. Capsaicin administration significantly ameliorated fasting glucose and insulin levels, reduced prostate weight and mitigated histopathological alterations. Furthermore, capsaicin treatment downregulated IGF\u20101 expression, suggesting its potential role in modulating IGF\u20101 signalling involved in cellular proliferation and differentiation and reversing prostate hyperplasia. These findings open up new avenue for exploring more about capsaicin as a possible therapeutic candidate for managing IR\u2010induced prostatic hyperplasia.<\/jats:p>","DOI":"10.1002\/jbt.70845","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:05:21Z","timestamp":1776323121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Capsaicin Mitigates Insulin Resistance\u2010Driven Prostate Hyperplasia Via IGF\u20101 Signalling Modulation in HFD\u2009+\u2009STZ Rat Model"],"prefix":"10.1002","volume":"40","author":[{"given":"Manvitha","family":"Kotaru","sequence":"first","affiliation":[{"name":"Department of Pharmacology, GITAM School of Pharmacy GITAM Deemed to be University Visakhapatnam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-6523","authenticated-orcid":false,"given":"Nihar","family":"Ranjan Das","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, GITAM School of Pharmacy GITAM Deemed to be University Visakhapatnam India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0555-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.01.019"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052430"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"S4","article-title":"Medical Therapy for Benign Prostatic Hyperplasia\u2010Present and Future Impact","volume":"13","author":"Issa M. 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