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Oxidative stress triggers the excessive generation of reactive oxygen species (ROS), which in turn elicits diverse forms of cellular injury, including cell cycle arrest. This study sought to investigate the role and underlying regulatory mechanism of miR\u201020b\u20105p in HQ\u2010induced cellular injury. The findings indicated that HQ increased the proportion of S\u2010phase cells, indicating S\u2010phase arrest. Furthermore, miR\u201020b\u20105p deletion facilitated the expression of nuclear factor erythroid 2\u2010related factor 2 (Nrf2) and its downstream proteins, while also stimulating the expression of downstream proteins associated with c\u2010Jun N\u2010terminal kinase 1 (JNK1). Therefore, we speculate that loss of miR\u201020b\u20105p exacerbates HQ\u2010induced cytotoxicity and S\u2010phase cell accumulation, potentially through the JNK1\/Nrf2 signaling pathway or via direct regulation of Nrf2.<\/jats:p>","DOI":"10.1002\/jbt.70866","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:32:39Z","timestamp":1777296759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MiR\u201020b\u20105p Is Involved in Hydroquinone\u2010Induced TK6 Cell Cycle Arrest and Oxidative Damage Through JNK1 Signaling Pathway and Targeting Nrf2"],"prefix":"10.1002","volume":"40","author":[{"given":"Pu","family":"Guo","sequence":"first","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Hu","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5422-6181","authenticated-orcid":false,"given":"Lingxue","family":"Yu","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewang","family":"Wang","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeqi","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Liang","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuanzhuan","family":"Li","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanwen","family":"Tang","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Luo","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health Guangdong Medical University Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"10","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/ijc.32202","article-title":"Residential Ambient Benzene Exposure in the United States and Subsequent Risk of Hematologic Malignancies","volume":"145","author":"Teras L. 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