{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:47:50Z","timestamp":1782110870317,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>We aimed to investigate the role and mechanism of LINC00852 in pancreatic cancer (PC), focusing on its regulation of glycolysis and tumor immunity through the miR\u2011494\u20113p\/GPX8 pathway. The expression of LINC00852, miR\u2010494\u20103p, and GPX8 in PC tissues and cells was detected, and Pearson's correlation analysis was used to assess their correlations. Kaplan\u2212Meier analysis evaluated the relationship between LINC00852 expression and patient survival. PANC\u20101 and AsPC\u20101 cells were cultured to examine proliferation, invasion, and apoptosis. Glycolysis was assessed by measuring glucose uptake and lactate production, while tumor immune function was evaluated through LDH release. A xenograft model was used to verify the in vivo oncogenic role of the LINC00852\/miR\u2010494\u20103p\/GPX8 axis. LINC00852 and GPX8 were highly expressed in PC tissues and cells, whereas miR\u2010494\u20103p showed low expression. Downregulation of LINC00852 or upregulation of miR\u2010494\u20103p inhibited proliferation and invasion, promoted apoptosis, and reduced glycolysis and tumor immune capacity. Inhibition of miR\u2010494\u20103p or overexpression of GPX8 partially reversed these effects. LINC00852 downregulation also suppressed tumor growth and immune evasion in mice. Mechanistically, LINC00852 bound to miR\u2010494\u20103p, which directly targeted GPX8. LINC00852 facilitates glycolysis and immune evasion in PC via the miR\u2011494\u20113p\/GPX8 axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.70871","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:12:36Z","timestamp":1779952356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LINC00852 Enhances Glycolysis and Tumor Immunity in Pancreatic Cancer via the miR\u2011494\u20113p\/GPX8 Axis"],"prefix":"10.1002","volume":"40","author":[{"given":"Changyuan","family":"Wang","sequence":"first","affiliation":[{"name":"Hepatobiliary Surgery Department \u2161 Guizhou Provincial People's Hospital Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8867-8889","authenticated-orcid":false,"given":"Bole","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Surgery, West China Hospital Sichuan University Chengdu Sichuan 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