{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:03:46Z","timestamp":1777867426973,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pneumonia, a respiratory infection that primarily affects the lungs, is a significant health concern in the pediatric population, often leading to hospitalization and, in severe cases, mortality. The present study was performed to investigate the therapeutic effects of the flavokawain A against mycoplasma pneumonia in mice. BALB\/c mice were subjected to an exposure with 100\u2009\u00b5L of\n                    <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>Mp<\/jats:italic>\n                    ) via nasal drips for a duration of 2 days, and subsequently administered 50\u2009mg\/kg of flavokawain A for a duration of 3 days. The pulmonary index (PI), survival percentage, and survival time was assessed in the experimental mice. The inflammatory biomarker concentrations (MPO and NO), oxidative stress biomarkers (MDA, SOD, and GSH), C\u2010reactive protein (CRP),\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010specific Ig\u2010M, and inflammatory cytokines were analyzed with the appropriate assay kits. The\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010DNA concentration were assessed in the experimental mice. The concentrations of JNK, ERK, and NF\u2010\u03baB in the lung tissues were assessed using kits. The histopathological examination was conducted on lung tissues to evaluate the histological alterations. The flavokawain A treatment significantly reduced the lethality and increased survival time in\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010induced mice. It also diminished the PI, NO, and MPO concentrations in\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010induced mice. The flavokawain A administration resulted in a reduction of MDA levels and an enhancement of antioxidants SOD and GSH levels. Flavokawain A treatment significantly diminished the levels of inflammatory cytokines, CRP,\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010specific Ig\u2010M, and\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010DNA content in the\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010infected mice. The histological results demonstrated a significant reduction in inflammatory signs and alveolar injury in the\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010induced mice. The current findings confirm the salutary properties of flavokawain A against\n                    <jats:italic>Mp<\/jats:italic>\n                    \u2010infected mice. Consequently, flavokawain A may serve as a talented therapeutic agent to treat pneumonia.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70878","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:16:18Z","timestamp":1777544178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavokawain A Mitigates\n                    <i>Mycoplasma pneumoniae<\/i>\n                    \u2010Induced Pneumonia by Inhibiting ERK\/JNK\/NF\u2010\u03baB Pathway in a Mouse Model"],"prefix":"10.1002","volume":"40","author":[{"given":"Helong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pediatric Internal Medicine Ankang Hospital of Traditional Chinese Medicine Ankang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatimah S.","family":"Al\u2010Khattaf","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anis","family":"ahamed","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2127-8418","authenticated-orcid":false,"given":"Cuicui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankang Hospital of Traditional Chinese Medicine Ankang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"issue":"5","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.4103\/jfmpc.jfmpc_1480_23","article-title":"Prevalence of Persistent Pneumonia Among Severe Pneumonia and Nutritional Status as Its Associated Risk Factor: A Prospective Observational Study Among Under\u2010Five Children","volume":"13","author":"Srivastava A. 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