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In CIA rats, CA treatment alleviated arthritis\u2010related signs, reduced inflammatory responses, and attenuated joint pathological damage. CA administration was also associated with restoration of intestinal barrier\u2010related features, including restoration of colonic histopathology and mucus layer integrity, as well as increased expression of tight junction proteins. Moreover, CA treatment was associated with altered gut microbiota composition. At the genus level, CA intervention was associated with increased abundance of\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    ,\n                    <jats:italic>Ligilactobacillus<\/jats:italic>\n                    , and\n                    <jats:italic>Ruminococcaceae<\/jats:italic>\n                    , which were negatively correlated with arthritis severity. CA treatment was associated with increased fecal SCFA levels in CIA rats. Collectively, these findings indicate that CA administration is associated with normalization of the gut microbiota, enhancement of intestinal barrier function, and amelioration of arthritis symptoms in CIA rats, suggesting that the interplay among gut dysbiosis, intestinal barrier damage, and arthritis may represent a contributing factor in the pathogenesis of RA.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70891","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T18:02:46Z","timestamp":1778090566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cinnamaldehyde Attenuates Collagen\u2010Induced Arthritis in Rats Through Immunomodulation and Alteration of Intestinal Flora Homeostasis and Repair of Intestinal Barrier Damage"],"prefix":"10.1002","volume":"40","author":[{"given":"Shuai","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqing","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyu","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjun","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-3796","authenticated-orcid":false,"given":"Xiaoqin","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine Hefei China"},{"name":"Institute of Pharmaceutics Anhui Academy of Chinese Medicine Hefei China"},{"name":"Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Hefei China"},{"name":"Engineering Technology Research Center of Modernized Pharmaceutics Anhui Education Department (AUCM) Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"issue":"10055","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid Arthritis","volume":"388","author":"Smolen J. 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