{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:09:06Z","timestamp":1793311746827,"version":"4.5.0"},"reference-count":83,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>With the advances in molecular diagnostics and newer treatment approaches, the overall survival and quality of life of patients have increased significantly. However, many anticancer drugs often cause ovarian damage or toxicity, leading to premature ovarian insufficiency, infertility, and serious long\u2010term psychosocial issues, making oncofertility an unmet need in current oncology practice. This manuscript addresses questions such as, \u201cWhat are the molecular pathways of anticancer drug\u2010induced ovarian toxicity in reproductive\u2010aged females and their clinical applications?\u201d and \u201cHow do oncofertility care models and regulation frameworks support fertility preservation in clinical oncology?\u201d Our goal is to provide a clear, comprehensive understanding of how major classes of anticancer drugs cause ovarian damage and to identify potential interventions to improve overall quality of life. From 2770 records, 52 studies were included. Mechanistic evidence shows distinct pathways: alkylating agents trigger oocyte apoptosis through TAp63\u03b1 activation; platinum drugs and anthracyclines cause mitochondrial dysfunction and oxidative stress; and taxanes interfere with oocyte meiotic spindles. Clinically, this results in measurable loss of ovarian reserves like anti\u2010Mullerian hormone (AMH) and antral follicle count (AFC), and decreased oocyte quality. Existing fertility preservation strategies, such as oocyte\/embryo and ovarian tissue cryopreservation, are effective, and gonadotropin\u2010releasing hormone (GnRH) agonists may offer additional protection. Ovarian toxicity from anticancer drugs represents a significant, drug\u2010specific survivorship challenge. Understanding these mechanisms is crucial for risk assessment. To minimize the long\u2010term impact on patients' quality of life, it is essential to incorporate proven fertility\u2010preservation techniques into routine oncology care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.70896","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:17:08Z","timestamp":1779261428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reproductive Toxicities of Anticancer Drugs in Females: A Systematic Review of Mechanisms, Consequences, Clinical Implications, and Oncofertility Care"],"prefix":"10.1002","volume":"40","author":[{"given":"Ahmed","family":"Aldarmahi","sequence":"first","affiliation":[{"name":"Basic Science Department, College of Science and Health Professions King Saud Bin Abdulaziz University for Health Sciences Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center Jeddah Saudi Arabia"},{"name":"Ministry of National Guard\u2014Health Affairs Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-4851","authenticated-orcid":false,"given":"Ashif","family":"Iqubal","sequence":"additional","affiliation":[{"name":"Medical Advisor Pfizer India Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_17_2_1","unstructured":"\u201cCancer Statistics Review 1975\u20102016 \u201d SEER Statistics accessed October 26 2025 https:\/\/seer.cancer.gov\/archive\/csr\/1975_2016\/."},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26157314"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.572388"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.2793"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14159-z"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2017.1335199"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.535"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1839"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00039-X"},{"key":"e_1_2_17_11_1","first-page":"105","article-title":"Fertility Preservation During Cancer Treatment: Clinical Guidelines","volume":"6","author":"Rodriguez\u2010Wallberg K. 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