{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:52:28Z","timestamp":1780584748515,"version":"3.54.1"},"reference-count":115,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Periodontitis is a chronic inflammatory disease, associated with immune reaction between pathogenic bacteria and host. It is characterized by localized reactive oxygen species (ROS) accumulation. Increased ROS accumulation leads to oxidative stress that can destruct the periodontal supporting tissues. Therefore, antibacterial, scavenging ROS, reducing the inflammatory response, regulating periodontal microenvironment, and alleviating alveolar bone resorption are effective methods to treat periodontitis. Recently, ROS\u2010responsive polymeric nanoparticles are being explored for their potential in releasing therapeutic agents for periodontitis treatment. This smart delivery method enhances treatment efficacy and pharmacokinetic properties while minimizing potential side effects. This review explores the potential of advanced these nanocarriers, their ROS\u2010sensitive properties, and their potential in improving periodontitis management.<\/jats:p>","DOI":"10.1002\/jbt.70900","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:41:22Z","timestamp":1778647282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymeric Nanoparticles for Modulating Reactive Oxygen Species in the Periodontitis Microenvironment"],"prefix":"10.1002","volume":"40","author":[{"given":"Suleiman Ibrahim","family":"Mohammad","sequence":"first","affiliation":[{"name":"Electronic Marketing and Social Media Economic and Administrative Sciences Zarqa University Zarqa Jordan"},{"name":"Research follower INTI International University Nilai Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asokan","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Faculty of Business and Communications INTI International University Nilai Malaysia"},{"name":"Shinawatra University Sam Khok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaleb","family":"Oriquat","sequence":"additional","affiliation":[{"name":"Faculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Qian","sequence":"additional","affiliation":[{"name":"Faculty of Accounting, Zibo Vocational Institute Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: From Microbial Immune Subversion to Systemic Inflammation","volume":"15","author":"Hajishengallis G.","year":"2015","journal-title":"Nature Reviews Immunology"},{"issue":"3","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4062\/biomolther.2021.001","article-title":"Recent Advances of Therapeutic Targets for the Treatment of Periodontal Disease","volume":"29","author":"Kim W. 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