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LPS could cause a dysregulation of host response to infection, which may lead to life\u2010threatening organ dysfunction. Accordingly, in our study, the probable protective impact of capmatinib against the LPS\u2010induced acute inflammatory response was explored and the possible causal mechanisms were examined. Male\n                    <jats:italic>Albino<\/jats:italic>\n                    mice were pretreated with capmatinib (5 or 10\u2009mg\/kg, daily,\n                    <jats:italic>orally<\/jats:italic>\n                    ) for 3 days then received single intraperitoneal injection of LPS (10\u2009mg\/kg) at day three. Capmatinib administration amended lung and testicular dysfunction as manifested by improved histopathological results and restored oxidant\/antioxidant balance. Capmatinib effectively down\u2010regulated protein kinase R\u2010like endoplasmic reticulum kinase\/phosphatidylinositol 3\u2010kinase (PERK\/PI3K) signaling pathway concomitant with toll\u2010like receptor 4\/nuclear factor kappa B (TLR4\/NF\u2010\u03baB) inflammatory pathway mitigation besides caspase\u20101\/gasdermin D (GSDMD)\u2010N\u2010terminal pathway inhibition. Collectively, the current study emphasized that capmatinib had potential protective effect against LPS\u2010induced pulmonary and testicular injury.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70916","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:23:22Z","timestamp":1779261802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Capmatinib Counteracts LPS\u2010Induced Pulmonary and Testicular Injury Through Attenuating TLR4\/NF\u2010\u03baB, PERK\/PI3K, and Caspase\u20101\/GSDMD Signaling Pathways"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-4441","authenticated-orcid":false,"given":"Esraa G.","family":"El\u2010Waseif","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara H.","family":"Hazem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-5533","authenticated-orcid":false,"given":"Dalia H.","family":"El\u2010Kashef","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada M.","family":"Suddek","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-18768-2_2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA04098B"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13527"},{"key":"e_1_2_11_5_1","first-page":"219","volume-title":"T\u2010cell Activation and LPS: A Dangerous duo for Organ Dysfunction","author":"Kerr A. 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