{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:47:43Z","timestamp":1782110863947,"version":"3.54.5"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This study aimed to develop a robust predictive model and nomogram for breast cancer (BC) based on genes associated with diverse cell death methods. A prognostic model was constructed using the LASSO Cox method, incorporating twelve genes (CREB3L1, SFRP1, SHARPIN, AIFM1, IL\u201118, CD24, EDA2R, CRIP1, XBP1, BCL2A1, NKX3\u20111, and NME5). BC patients were classified into high\u2011risk and low\u2011risk subgroups, with the low\u2011risk subgroup showing superior survival, and this prognostic value was validated in an independent external cohort. A nomogram was also developed and confirmed as a reliable independent predictor of outcome. Enrichment analyses suggested a link between patient risk and immune response. The low\u2011risk subgroup exhibited a higher tumor microenvironment (TME) score. Patients in the high\u2011risk group showed improved responses to lapatinib, BI\u20112536, OSI\u2011027, and SB505124, whereas those in the low\u2011risk subgroup had better sensitivity to axitinib, epirubicin, fulvestrant, and olaparib. Additionally, CD24 overexpression in BC cell lines promoted proliferation and migration, and inhibited apoptosis. These findings contribute to personalized treatment strategies and help elucidate the tumor microenvironment characteristics of BC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.70919","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:11:41Z","timestamp":1780337501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Construction of a Breast Cancer Predictive Nomogram Based on Diverse Cell Death Methods and Reveal Tumor Microenvironment Characterization"],"prefix":"10.1002","volume":"40","author":[{"given":"Rihan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Wang","sequence":"additional","affiliation":[{"name":"Medicine School of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanrui","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ninth Hospital of Xi'an Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center, People's Hospital of Ningxia Hui Autonomous Region Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9855-1086","authenticated-orcid":false,"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105320"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021967"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041588"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.07.036"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj329"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180992"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701320337"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2070"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01143-y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10787"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2381"},{"issue":"6","key":"e_1_2_10_14_1","first-page":"1408","article-title":"Detection of Proteins Associated With the Pyroptosis Signaling Pathway in Breast Cancer Tissues and Their Significance","volume":"13","author":"Wu X.","year":"2020","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.021"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172308"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00630-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2021.09.003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00946-7"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05384-6"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00866-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01229-y"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01732-y"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01091-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1198878"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106936"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac033"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1170-y"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2019.01.006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.847345"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu191"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.14712\/18059694.2016.63"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0913-y"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI139905"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67428"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02302-5"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001341"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.04.010"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-03166-4"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500722"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217116"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01052-y"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00090"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0672-x"},{"issue":"3","key":"e_1_2_10_46_1","first-page":"641","article-title":"Loss of SFRP1 Is Associated With Breast Cancer Progression and Poor Prognosis in Early Stage Tumors","volume":"25","author":"Klopocki E.","year":"2004","journal-title":"International Journal of Oncology"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2317"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109414"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20368"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2017.07.004"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.018"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2021.22.1.131"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115536"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12515"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1456-0"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-04124-x"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-28"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13119"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S388990"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205575110"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210363"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01267-6"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2019.3016"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0949-9"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1055-9"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33249"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70919","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:04:50Z","timestamp":1782108290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jbt.70919"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70919","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2024-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70919"}}