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The present study identifies oxidative signalling as a key mechanism of cyclophosphamide\u2010mediated liver, kidney, and brain injury and evaluates dose\u2010dependent protective effects of ellagic acid, a natural dietary polyphenol. Male Wistar rats were orally pretreated with ellagic acid (10, 20, 30, and 40\u2009mg\/kg) for 6 days before receiving a single intraperitoneal dose of cyclophosphamide (200\u2009mg\/kg) on Day 6 to reliably induce multiple organ injury within 24\u2009h. Animals were euthanized 24\u2009h after administration of the last dose of cyclophosphamide for serological, tissue biochemical, and histological assessments. Cyclophosphamide significantly altered liver and kidney function markers, increased lipid peroxidation, and depleted antioxidant enzyme activities, confirming oxidative stress\u2010driven injury. Severe deformities in the tissue architecture of liver, kidney, and brain were also evident after exposure to cyclophosphamide. Ellagic acid markedly restored antioxidant defense system, normalized biochemical indices, and preserved tissue integrity in a dose\u2010dependent manner. These findings revealed mechanistic interplay between oxidative stress and systemic injury and demonstrated that ellagic acid effectively mitigates adverse effects of cyclophosphamide\u2010induced multiple organ injury.<\/jats:p>","DOI":"10.1002\/jbt.70925","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:50:48Z","timestamp":1780465848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ellagic Acid Protects Multiple Organ Injury Induced by Cyclophosphamide\u2010Mediated Oxidative Stress: Biochemical and Histological Insights"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7047-1818","authenticated-orcid":false,"given":"Asim Amitabh","family":"Sahu","sequence":"first","affiliation":[{"name":"Toxicology and Pharmacology Laboratory, Department of Zoology Guru Ghasidas University Koni\u2010Bilaspur Chhattisgarh 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