{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:47:37Z","timestamp":1782110857308,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sepsis is a life\u2010threatening systemic inflammatory response syndrome. The long non\u2010coding RNA SATB1\u2010AS1 exhibits abnormal expression in blood samples from sepsis patients. This study explores the regulatory role of SATB1\u2010AS1 in sepsis. This study included 58 patients with sepsis and 42 patients with non\u2010septic infections. RT\u2010qPCR was used to detect the expression levels of SATB1\u2010AS1 and miR\u2010124\u20103p. ROC analysis evaluated the diagnostic value of SATB1\u2010AS1. In an LPS\u2010induced RAW264.7 sepsis model, macrophage differentiation markers, cell proliferation, apoptosis, and inflammatory factor levels were assessed via RT\u2010qPCR, CCK\u20108 assay, flow cytometry, and ELISA, respectively. DLR and RIP experiments validated the binding relationship between SATB1\u2010AS1 and miR\u2010124\u20103p. SATB1\u2010AS1 was significantly overexpressed in the serum of sepsis patients, demonstrating good diagnostic value. Conversely, miR\u2010124\u20103p is downregulated, with both molecules exhibiting targeted binding and negatively correlated expression levels. Knocking down SATB1\u2010AS1 increases miR\u2010124\u20103p levels, enhances cellular proliferation, reduces apoptosis rates, promotes macrophage M2 polarization, and decreases TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2 release. SATB1\u2010AS1 holds promise as a novel diagnostic biomarker for sepsis. By binding to miR\u2010124\u20103p, it promotes the release of inflammatory cytokines from macrophages, thereby exacerbating the pathological progression of sepsis. The SATB1\u2010AS1\/miR\u2010124\u20103p axis may emerge as a new therapeutic target for sepsis.<\/jats:p>","DOI":"10.1002\/jbt.70929","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:56:08Z","timestamp":1781160968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Upregulation of lncRNA SATB1\u2010AS1 in Serum Promotes Sepsis Progression By Suppressing miR\u2010124\u20103p and Enhancing Inflammatory Mediator Release"],"prefix":"10.1002","volume":"40","author":[{"given":"Lihong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow University Suzhou 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