{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:06:43Z","timestamp":1787792803420,"version":"build-2784847793"},"reference-count":99,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cancers such as oral, esophageal, gastric, pancreatic, and colorectal malignancies represent a significant global health burden. Amid continuous efforts to develop effective pharmacological interventions, the natural flavonoid luteolin, which is found to be abundantly present in various dietary sources, has gained consideration as a potential therapeutic agent for the management of these malignancies. This review provides a succinct overview of current strategies and potential perspectives concerning the established role of luteolin in preventing such cancers. The multifaceted protective mechanism\/s offered by luteolin are contributed by its antioxidative, anti\u2010inflammatory, and anti\u2010proliferative properties, thus characterizing it as a potent drug candidate against gastrointestinal cancers. Recent findings have emphasized its precise targeting of cancer cells without affecting healthy tissues, thus marking its potential in precision medicine. Particularly, the impact of luteolin on limiting esophageal and gastric cancers is mediated by alleviating oxidative stress, inhibiting chronic inflammation, and significant induction of apoptosis. Such findings accentuate the potential of luteolin for considering it as a pivotal molecule in personalized preventive interventions. The futuristic perspective investigations uncovering luteolin's precise mechanism of action and subsequent establishment of its targeted delivery system are warranted to further strengthen its efficacy in managing such malignancies.<\/jats:p>","DOI":"10.1002\/jbt.70934","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:51:43Z","timestamp":1780923103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Luteolin in Prevention of Oral, Esophageal, Gastric, Pancreatic, and Colon Cancers: Recent Trends and Future Perspectives"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-4493","authenticated-orcid":false,"given":"Abhilasha","family":"Sood","sequence":"first","affiliation":[{"name":"Department of Allied Health Sciences, Chitkara School of Health Sciences Chitkara University  Rajpura Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-0247","authenticated-orcid":false,"given":"Arpit","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Allied Health Sciences, Chitkara School of Health Sciences Chitkara University  Rajpura Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7597-2400","authenticated-orcid":false,"given":"Soniya","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Sciences and Technology, Maharishi Markandeshwar Engineering College Maharishi Markandeshwar  Ambala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-1980","authenticated-orcid":false,"given":"Bunty","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Graphic Era (Deemed to be University)  Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-080X","authenticated-orcid":false,"given":"Ujjawal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Molecular Medicine Central University of Punjab  Bathinda India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2989-121X","authenticated-orcid":false,"given":"Shafiul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Nursing and Health Sciences, and Health Research Center Jazan University  Jazan Saudi Arabia"},{"name":"School of Medicine Universidad Espiritu Santo  Samborondon Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damandeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"University Centre for Research &amp; Development (UCRD), Chandigarh University  Mohali India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-0094","authenticated-orcid":false,"given":"Hardeep Singh","family":"Tuli","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Sciences and Technology, Maharishi Markandeshwar Engineering College Maharishi Markandeshwar  Ambala India"},{"name":"Centre of Excellence in Computational Research and Drug Discovery Maharishi Markandeshwar (Deemed to be University)  Mullana, Ambala Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321600"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10010119"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-1038"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13142399"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010105"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11030554"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108612"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.05.019"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800908786241050"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.4091"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.11.007"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gel033"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23482"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6380"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.06.140"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.27183"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29051093"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.05.056"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061155"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14994"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-018-3680-1"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf505848z"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955709787001712"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-005-4584-1"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.05.019"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b06954"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800908786241050"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26701"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2023.1603"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2300200"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700413"},{"key":"e_1_2_13_34_1","first-page":"22","article-title":"Esophageal Cancer","volume":"95","author":"Short M. W.","year":"2017","journal-title":"American Family Physician"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1088314"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.01.021"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2019.03.014"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01099-7"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15832"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.04.056"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.38"},{"key":"e_1_2_13_42_1","first-page":"33","article-title":"Assessing the Potential of Gastroretentive Technology for Gastric Cancer Targeting","volume":"13","author":"Saini S.","year":"2023","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"e_1_2_13_43_1","first-page":"2151","article-title":"Nano\u2010Based Approaches for Diagnosis and Therapy of Gastric Cancer","volume":"109","author":"Rai A.","year":"2023","journal-title":"International Journal of Surgery"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9396512"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(97)00261-9"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977770"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2015.09.002"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.12.003"},{"key":"e_1_2_13_49_1","first-page":"3842","article-title":"Luteolin Inhibits Cell Cycle Progression and Induces Apoptosis of Breast Cancer Cells Through Downregulation of Human Telomerase Reverse Transcriptase","volume":"17","author":"Huang L.","year":"2019","journal-title":"Oncology Letters"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.7785\/tcrt.2012.500434"},{"key":"e_1_2_13_51_1","first-page":"15190","article-title":"The Flavonoid Luteolin Enhances Doxorubicin\u2010Induced Autophagy in Human Osteosarcoma U2OS Cells","volume":"8","author":"Zhang B.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO00033F"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S91511"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgab017"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215373"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR06638J"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-22-507"},{"issue":"78","key":"e_1_2_13_58_1","first-page":"494","article-title":"Luteolin Suppressed Growth of Colon Tumor via Inflammation, Oxidative Stress, and NLRP3\/IL\u20101\u03b2 Signal Axis","volume":"18","author":"Yao Q.","year":"2022","journal-title":"Pharmacognosy Magazine"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14123001"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.952587"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b03273"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112098"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01529H"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083564"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1703"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47020126"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/19476337.2024.2381714"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3104"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.11.5455"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6380"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047796"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040770"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29071570"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01596-8"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173210"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27275"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14987"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174337"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.13134"},{"key":"e_1_2_13_80_1","first-page":"1106","article-title":"Luteolin Induces Myelodysplastic Syndrome\u2010Derived Cell Apoptosis via the p53\u2010dependent Mitochondrial Signaling Pathway Mediated by Reactive Oxygen Species","volume":"42","author":"Dong W.","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_13_81_1","first-page":"1","article-title":"Mechanisms of Luteolin Against Gastro\u2010Esophageal Reflux Disease Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation","volume":"24","author":"Wang X.","year":"2024","journal-title":"Cell Biochemistry and Biophysics"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.14.5501"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3322"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16081161"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2678-2"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.08.020"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2021.1900301"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.6.2911"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_438_18"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S400329"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127286"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c05628"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2809"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16220-4"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13102628"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1080\/16583655.2020.1812269"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111749"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1720"},{"issue":"1","key":"e_1_2_13_99_1","first-page":"37","article-title":"New Developments in Nf\u2010\u039ab Inhibitors Derived From Natural Products For The Treatment of Cancer and Inflammation","volume":"1","author":"Chandra R.","year":"2025","journal-title":"Indian Journal of Pharmaceutical Chemistry and Analytical Techniques"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1710"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:02:54Z","timestamp":1782108174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":99,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jbt.70934"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70934","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70934"}}