{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:47:35Z","timestamp":1782110855807,"version":"3.54.5"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetes mellitus exerts a deleterious effect on the male reproductive system, manifesting as a metabolic disease. Recent research has indicated that the ingestion of dietary supplements rich in natural antioxidants may reduce or prevent damage to the male reproductive system in cases of diabetes\u2010induced infertility. This study investigated the effects of zingerone on diabetes\u2010induced reproductive damage in male rats by analyzing the Sirt1\/Nrf2\/HO\u20101 signaling pathway, apoptosis, sperm quality, and histopathological changes. Seventy\u2010five male Sprague Dawley rats, weighing between 250 and 300\u2009g and aged 10 to 12 weeks, were divided into six groups. These included: control; zingerone (50\u2009mg\/kg); zingerone (100\u2009mg\/kg); diabetes; diabetes with zingerone (50\u2009mg\/kg); and diabetes with zingerone (100\u2009mg\/kg). Diabetes was induced via a single intraperitoneal injection of 55\u2009mg\/kg streptozotocin. Zingerone was given daily by oral gavage for a duration of 8 weeks. Results showed that zingerone significantly reduced glucose, MDA levels, and the Bax\/Bcl\u20102 ratio, while markedly enhancing body weight, testosterone, GSH content, GSH\u2010Px and CAT enzyme activity, and the expression of Sirt1, Nrf2, and HO\u20101. Additionally, it had a beneficial impact on spermatological parameters and histopathological findings in diabetic rats. The findings from this study, obtained from both healthy and diabetic rats, are consistent with each other, thereby providing a reliable basis for the conclusions drawn. Thus, incorporating zingerone into prophylactic regimens for healthy rats and therapeutic interventions for diabetic conditions may be advisable. Furthermore, combination drug therapies including zingerone may offer a viable approach to mitigating the toxic effects associated with certain drugs and to combating diabetes\u2010related infertility. Consequently, it was concluded that zingerone ameliorates diabetes\u2010induced damage to the male reproductive system, with 100\u2009mg\/kg zingerone demonstrating superior efficacy.<\/jats:p>","DOI":"10.1002\/jbt.70939","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:03:42Z","timestamp":1780337022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Effect of Zingerone on Reproductive Damage in Diabetic Male Rats: Potential Role of Sirt1\/Nrf2\/HO\u20101 and Bax\/Bcl\u20102 Signaling Pathways"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-7592","authenticated-orcid":false,"given":"Edanur G\u00fcler","family":"Ekmen","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine F\u0131rat University Elaz\u0131\u011f T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"\u00c7ay","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine F\u0131rat University Elaz\u0131\u011f T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-1478","authenticated-orcid":false,"given":"\u0130brahim Halil","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine F\u0131rat University Elaz\u0131\u011f T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Osman","family":"\u00c7eriba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine F\u0131rat University Elaz\u0131\u011f T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119605"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.12.013"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12891"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122220"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23593"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13938"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06858-0"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/816364"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13241"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-013-9801-x"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"1","article-title":"Modulatory Effect of Zingerone Against STZ\u2010Nicotinamide Induced type\u20102 Diabetes Mellitus in Rats","volume":"127","author":"Anwer T.","year":"2019","journal-title":"Archives of Physiology and Biochemistry"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.03.005"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.06.017"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13899"},{"issue":"9","key":"e_1_2_12_17_1","first-page":"1098","article-title":"Protective Effects of Zingerone Against Sodium Arsenite\u2010Induced Lung Toxicity: A Multi\u2010Biomarker Approach","volume":"26","author":"\u015eim\u015fek H.","year":"2023","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00072.2024"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2014.1003534"},{"issue":"3","key":"e_1_2_12_20_1","first-page":"1","article-title":"\u00c7ay M. 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