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Ferulic acid (FA), a plant\u2010derived polyphenol, possesses antioxidant and anti\u2010inflammatory characteristics, yet its role in diabetic atherosclerosis remains underexplored. In the current study, we explore the anti\u2010atherosclerosis effects of FA against diabetes\u2010induced atherosclerosis in rats. Forty male Wistar rats received a high\u2010fat diet, streptozotocin, and vitamin D3 to induce atherosclerosis. Rats were divided into control, atherosclerotic, and treated with FA (50\u2009mg\/kg, daily for 7\u2009weeks as preventive and 3\u2009weeks as therapeutic) or rosuvastatin (5\u2009mg\/kg, daily for 7\u2009weeks). Body weight, biochemical, molecular, and histopathological analyses were conducted. Atherosclerotic rats exhibited significant hyperglycemia, dyslipidemia, inflammation, and vascular injury. FA administration obviously improved body weight, fasting and postprandial glucose levels, lipid profile, and cardiovascular indices. Moreover, FA significantly reduced serum oxLDL, MDA, and NO levels, while it significantly increased serum activities of both SOD and GPX, besides GSH levels. FA treatment significantly downregulated NF\u2010\u03baB p65, iNOS, and MMP\u20109 aortic protein levels. Additionally, serum pro\u2010inflammatory cytokines (TNF\u2010\u03b1 and MCP\u20101) were reduced, while serum levels of anti\u2010inflammatory IL\u201010 were improved in FA\u2010treated atherosclerotic rats. Serum miR\u201027 and miR\u201029 expression levels were significantly modulated after treatment with FA. The overall results suggested that FA confers multi\u2010targeted protection against diabetic atherosclerosis through modulation of metabolic, oxidative stress, inflammatory, and epigenetic pathways. These findings highlight its potential as a complementary or preventative approach in the management of vascular diseases associated with diabetes.<\/jats:p>","DOI":"10.1002\/jbt.70940","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:53:32Z","timestamp":1780383212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferulic Acid Suppresses Diabetes\u2010Induced Atherosclerosis by Targeting Oxidative Stress, NF\u2010\u03baB p65\/iNOS, and miRNAs Pathways"],"prefix":"10.1002","volume":"40","author":[{"given":"Taqwa A.","family":"Abdelhamed","sequence":"first","affiliation":[{"name":"Technology of Medical Laboratories Department, Faculty of Applied Health Sciences Technology Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-4268","authenticated-orcid":false,"given":"Ahmed A. 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