{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:47:50Z","timestamp":1782110870355,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study examined the impact of vitamin D (Vit D) treatment on oxidative stress in the brain caused by cisplatin (CP). A total of 21 Wistar Albino rats were allocated into three groups: control; CP, which received a single dose of 7\u2009mg\/kg CP on the first day; and VitD\u2009+\u2009CP (administered a single dose of 7\u2009mg\/kg CP on the first day followed by 1000\u2009IU\/mL Vit D for 7 days). The brain was removed immediately after the experiment. Biochemical oxidative stress (OSI), total antioxidant status (TAS), and total oxidant status (TOS) were calculated in left hemisphere tissue samples. In addition, measurements of pro\u2010inflammatory cytokines such as TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 were also performed in this tissue. We examined tissue samples from the right hemisphere using histological and immunohistochemical methods to detect Nrf2, HO\u20101, BEC\u20101, and LC3 proteins. Biochemical analyses revealed a slight increase in TOS and a slight decrease in TAS in the CP group, while in the VitD\u2009+\u2009CP group, TOS decreased slightly and TAS increased significantly. The differences between the groups were not statistically significant. Furthermore, the OSI value increased statistically significantly in the CP group, while it decreased statistically significantly in the VitD\u2009+\u2009CP group. In the cerebral cortex of the CP group, widespread degenerate neurons were observed, characterized by dark pyknotic nuclei. Furthermore, the results indicated that CP administration induced a significant increase in HO\u20101 immunoreactivity, reflecting a compensatory activation of the Nrf2\u2010mediated antioxidant response. Moreover, Nrf2, HO\u20101, and LC3 immunoreactivity were found to be significantly lower in the VitD\u2009+\u2009CP group compared to the CP group. Overall, VitD shows potential as an adjunctive agent against CP neurotoxicity, pending further mechanistic validation.<\/jats:p>","DOI":"10.1002\/jbt.70941","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:48:10Z","timestamp":1780382890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitigation of Cisplatin\u2010Induced Neurotoxicity via Nrf2\/HO\u20101 Signaling and Autophagy: The Protective Role of Vitamin D"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-1425","authenticated-orcid":false,"given":"Songul","family":"Cuglan","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine \u0130stanbul Atlas University \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-7867","authenticated-orcid":false,"given":"Azibe","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2099-2273","authenticated-orcid":false,"given":"Kevser","family":"Tanbek","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Inonu University Malatya 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