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This study was designed to investigate the effects of tocilizumab and dexamethasone on antioxidant and proinflammatory cytokines in acute renal injury in rats with an oleic acid\u2010induced ARDS model. Six groups of rats were included in the research: (i) the CN group, (ii) OA group, (iii) OA\u2009+\u2009TCZ\u20102 group, (iv) OA\u2009+\u2009TCZ\u20104 group, (v) OA\u2009+\u2009DEX\u20100.1 group, and (vi) OA\u2009+\u2009DEX\u201010 group. The lipid peroxidation levels and superoxide dismutase activities in the kidneys were statistically decreased in the OA\u2009+\u2009TCZ\u20104 group. Glutathione levels were increased in the kidneys of rats in the OA group. Catalase activity increased in the OA\u2009+\u2009TCZ\u20104 and OA\u2009+\u2009DEX\u201010 groups. Tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) and interleukin\u201033 (IL\u201033) expression levels decreased in the OA\u2009+\u2009TCZ\u20104 group. Histopathological findings such as atrophy\/hypertrophy in the glomerulus, degeneration and necrosis in the tubular epithelium, hyaline debris in the tubule lumen, and capillary congestion were less prevalent in the OA\u2009+\u2009TCZ\u20104 group. Renal SEM imaging revealed severe podocyte surface deterioration and structural damage to tubules in the OA, OA\u2009+\u2009TCZ\u20102 and OA\u2009+\u2009DEX\u201010 groups. Tocilizumab treatment at a dose of 4\u2009mg\/kg appeared to be more effective in certain evaluated parameters compared to other treatments in improving renal glomerular and tubular damage, expression levels of proinflammatory cytokines (TNF\u2010\u03b1 and IL\u201033), and antioxidant parameters in cases of oleic acid\u2010induced ARDS.<\/jats:p>","DOI":"10.1002\/jbt.70947","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:45:10Z","timestamp":1780465510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tocilizumab and Dexamethasone Reduce TNF\u2010\u03b1 and IL\u201033 and Oxidative Stress in Kidney Tissue in Oleic Acid\u2010Induced ARDS Model"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-536X","authenticated-orcid":false,"given":"Huseyin Serkan","family":"Erol","sequence":"first","affiliation":[{"name":"Department of 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