{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:14:10Z","timestamp":1790079250076,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) is a common refractory reproductive endocrine disorder in women. It is urgent to identify reliable biomarkers and explore the underlying molecular mechanisms of PCOS pathogenesis. A total of 199 subjects were enrolled in this study, including 108 PCOS patients and 91 healthy people. MiR\u2010191\u20105p expression and diagnostic value were evaluated utilizing RT\u2010qPCR and the ROC curve. Chi\u2010square test was utilized to assess the correlation between baseline characteristics and miR\u2010191\u20105p level in PCOS patients. The target gene of miR\u2010191\u20105p was predicted by the TargetScan database. The correlation between miR\u2010191\u20105p and SOX4 in PCOS was analyzed using Pearson's correlation. In KGN cells, miR\u2010191\u20105p and SOX4 were overexpressed or inhibited using Lipofectamine 3000. Factors related to ferroptosis and proliferation were detected by CCK\u20108 assay, ferroptosis\u2010related factors kits, and RT\u2010qPCR. miR\u2010191\u20105p was downregulated in PCOS and presented good diagnostic efficiency. miR\u2010191\u20105p is closely related to baseline characteristics of PCOS and serves\u00a0as a risk factor for PCOS. In KGN cells, overexpression of miR\u2010191\u20105p promoted proliferation and suppressed ferroptosis, while inhibition of miR\u2010191\u20105p reduced proliferation and increased ferroptosis. In PCOS, SOX4 was identified as a downstream target of miR\u2010191\u20105p and was negatively regulated by miR\u2010191\u20105p. In KGN cells, overexpression of SOX4 reduced proliferation and increased ferroptosis. miR\u2011191\u20115p is aberrantly expressed in PCOS and may serve as a potential diagnostic biomarker. miR\u2011191\u20115p participates in the progression of PCOS by negatively regulating SOX4 and modulating cell proliferation and ferroptosis.<\/jats:p>","DOI":"10.1002\/jbt.70974","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:03:13Z","timestamp":1783580593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["miR\u2010191\u20105p Is Involved in Polycystic Ovary Syndrome by Targeting SOX4"],"prefix":"10.1002","volume":"40","author":[{"given":"Juan","family":"Du","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Heilongjiang China"},{"name":"Gynecology Ward 1 Heilongjiang Zhongyiyaodaxue Fushu Dier Yiyuan Harbin Heilongjiang 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