{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:13:57Z","timestamp":1790079237965,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of novel sulfonamide derivatives (\n                    <jats:bold>4a<\/jats:bold>\n                    \u2013\n                    <jats:bold>i<\/jats:bold>\n                    ) was synthesized via a three\u2010step sequence involving Schiff base formation, sodium borohydride reduction to the corresponding secondary amines (\n                    <jats:bold>2a<\/jats:bold>\n                    \u2013\n                    <jats:bold>i<\/jats:bold>\n                    ), and subsequent treatment with\n                    <jats:italic>p<\/jats:italic>\n                    \u2010toluenesulfonyl chloride in the presence of sodium carbonate. The structures of all intermediates and final products were unambiguously confirmed by FT\u2010IR,\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and HRMS analyses. The antioxidant activity of the target compounds was assessed using the DPPH radical scavenging assay with BHT as a reference standard. Among the synthesized derivatives, compound\n                    <jats:bold>4d<\/jats:bold>\n                    exhibited the most pronounced antioxidant activity, surpassing BHT at concentrations of 37.5 and 62.5\u2009\u00b5g\/mL. The cytotoxicity of the compounds was evaluated against human ovarian carcinoma (A2780) and prostate cancer (LNCaP) cell lines using the MTT assay, with docetaxel as a positive control. Compounds\n                    <jats:bold>4g<\/jats:bold>\n                    ,\n                    <jats:bold>4h<\/jats:bold>\n                    , and\n                    <jats:bold>4i<\/jats:bold>\n                    demonstrated the highest cytotoxic potency against both cell lines, with compound\n                    <jats:bold>4h<\/jats:bold>\n                    displaying a log IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 1.343\u2009\u00b5g\/mL against LNCaP cells. Structure\u2013activity relationship analysis suggests that the methoxy substituent enhances cytotoxic activity, likely through increased lipophilicity and electron\u2010donating effects facilitating interactions with biological targets. Molecular docking studies were performed to further rationalize the observed biological activities.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70981","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:14:01Z","timestamp":1782198841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Characterization, Antioxidant Evaluation, Cytotoxicity Studies, and Molecular Docking of Novel Sulfonamide Derivatives"],"prefix":"10.1002","volume":"40","author":[{"given":"Ouissal","family":"Bouraoui","sequence":"first","affiliation":[{"name":"Laboratory of Natural Products of Plant Origin and Organic Synthesis Fr\u00e8res Mentouri University Constantine 1  Constantine Algeria"},{"name":"Department of Chemistry, Faculty of Arts and Sciences \u0130nonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-4454","authenticated-orcid":false,"given":"G\u00fcldeniz","family":"\u015eekerci","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine \u0130n\u00f6n\u00fc University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Mesbah","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products of Plant Origin and Organic Synthesis Fr\u00e8res Mentouri University Constantine 1  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-6954","authenticated-orcid":false,"given":"James A.","family":"Ezugwu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences \u0130nonu University  Malatya Turkey"},{"name":"Department of Pure and Industrial Chemistry University of Nigeria  Nsukka Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Benkiniouar","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products of Plant Origin and Organic Synthesis Fr\u00e8res Mentouri University Constantine 1  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-1802","authenticated-orcid":false,"given":"Suat","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine \u0130n\u00f6n\u00fc University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fat\u00fcmet\u00fczzehra","family":"K\u00fc\u00e7\u00fckbay","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, \u0130nonu University Faculty of Pharmacy  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-8583","authenticated-orcid":false,"given":"Houssem","family":"Boulebd","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis of Molecules with Biological Interest, Department of Chemistry, Faculty of Exact Sciences University Fr\u00e8res Mentouri Constantine 1  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-9486","authenticated-orcid":false,"given":"Hasan","family":"K\u00fc\u00e7\u00fckbay","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences \u0130nonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051604"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867033457647"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272822666180122153839"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.70180"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.08.032"},{"key":"e_1_2_10_7_1","article-title":"Synthesis, Molecular Docking Study of Benzoylated Sulfonamide and Benzamide Conjugates of 7\u2010Chloroquinoline with Antioxidant and Antimicrobial Activity","volume":"11","author":"Ezugwu J. 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