{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:13:53Z","timestamp":1790079233245,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nasopharyngeal carcinoma (NPC) is a prevalent malignancy with a distinct geographical distribution. This study aimed to identify core glycolysis\u2010related genes and investigate their functional roles in NPC pathogenesis. Integrated transcriptomic analysis was performed on multiple Gene Expression Omnibus datasets. Screening of core genes was performed computationally via machine learning algorithms on the pool of glycolysis\u2010related differentially expressed genes (Gly\u2010DEGs). The tumor\u2010suppressive function of insulin\u2010like growth factor 1 (IGF1) was demonstrated through a combination of in vitro assays, assessing proliferation, migration, invasion, apoptosis, and glycolysis, followed by validation in xenograft models. Co\u2010immunoprecipitation (Co\u2010IP) examined IGF1\u2010PGM5 interaction; Western blotting measured IGF1R and p\u2010IGF1R levels. PGM5 involvement was tested by knockdown rescue. IGF1 was identified as a significantly downregulated core gene in NPC. Its overexpression inhibited NPC cell proliferation, migration, invasion, and promoted apoptosis, while simultaneously suppressing glycolysis, evidenced by reduced glucose consumption, lactate production, and expression of key glycolytic enzymes hexokinase 2 (HK2) and lactate dehydrogenase A (LDHA). These findings were corroborated in vivo. Co\u2010IP revealed a direct physical interaction between IGF1 and PGM5. IGF1 overexpression did not alter total IGF1R or p\u2010IGF1R levels, indicating IGF1R\u2010independent action. IGF1 positively correlated with PGM5, and PGM5 knockdown attenuated IGF1's tumor\u2010suppressive and glycolytic\u2010inhibitory effects. In NPC, IGF1 serves to suppress tumor progression, inhibiting malignant phenotypes and aerobic glycolysis through the upregulation of PGM5. The IGF1\u2010PGM5 axis represents a novel metabolic regulatory pathway that may warrant further investigation as a potential therapeutic target for NPC intervention.<\/jats:p>","DOI":"10.1002\/jbt.70988","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:30:05Z","timestamp":1782750605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The IGF1\u2010PGM5 Axis Inhibits Aerobic Glycolysis and Serves As a Tumor Suppressor in Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2876-7218","authenticated-orcid":false,"given":"Xiaolin","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixue","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-2481","authenticated-orcid":false,"given":"Shuxin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6835-8751","authenticated-orcid":false,"given":"Wenjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30956-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1702"},{"key":"e_1_2_10_4_1","unstructured":"Z. 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