{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:34:13Z","timestamp":1792956853642,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Myocardial infarction (MI) usually results in severe heart failure (HF), and patients suffer from the repercussions of MI, elucidation of the pathological basis of MI is crucial to optimize the prevention and treatment of MI. This study investigated the role of dysregulated circ_0001112 in MI. In our study, circ_0001112 was significantly upregulated in the MI model and by hypoxia treatment. Circ_0001112 overexpression inhibited hypoxia\u2010induced cardiomyocyte apoptosis. Luciferase assay showed that circ_0001112 sponged miR\u2010324\u20105p that regulated the expression of cyclin\u2010dependent kinase 6 (\n                    <jats:italic>CDK6<\/jats:italic>\n                    ). Ago2\u2010miRNP immunoprecipitation further confirmed that the 3\u2032\u2010untranslated region (3'UTR) of\n                    <jats:italic>CDK6<\/jats:italic>\n                    was targeted by miR\u2010324\u20105p. Either miR\u2010324\u20105p overexpression or CDK6 knockdown prevented cardiomyocyte apoptosis induced by circ_0001112 overexpression. In conclusion, this study demonstrated that the downregulation of circ_0001112 promoted cardiomyocyte apoptosis by sponging miR\u2010324\u20105p and upregulating CDK6 expression in MI.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70995","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:46:29Z","timestamp":1787240789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Downregulation of circ_0001112 Enhances Myocardial Infarction Through Regulation of miR\u2010324\u20105p\/CDK6 Axis"],"prefix":"10.1002","volume":"40","author":[{"given":"Aizhen","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Affiliated Yantai Yuhuangding Hospital Qingdao University Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Yantai Yuhuangding Hospital Qingdao University Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingping","family":"Men","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Yantai Yuhuangding Hospital Qingdao University Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-025-01186-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_122_20"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae885"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"135","article-title":"Characteristics of Plant Circular RNAs","volume":"21","author":"Chu Q.","year":"2020","journal-title":"Briefings in 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