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Although miR\u201030a\u20105p participates in the pathogenesis of various malignancies, detailed molecular mechanisms in CRC remain largely uncharacterized. By analyzing GEO public datasets and performing RT\u2010qPCR, we determined that miR\u201030a\u20105p was downregulated in CRC. Functional assays confirmed that miR\u201030a\u20105p overexpression inhibited the migration and epithelial\u2013mesenchymal transition (EMT) of CRC cells. Mechanistically, miR\u201030a\u20105p directly targeted vimentin, thereby suppressing downstream ERK signaling pathway activation. Taken together, our findings indicate that miR\u201030a\u20105p functions as a tumor suppressor in CRC, suggesting that the miR\u201030a\u20105p\/vimentin axis represents a potential therapeutic target for CRC treatment.<\/jats:p>","DOI":"10.1002\/jbt.71002","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:17:42Z","timestamp":1782749862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MiR\u201030a\u20105p Suppresses the ERK Signaling Pathway by Targeting Vimentin to Inhibit the Migration and Epithelial\u2013Mesenchymal Transition of Colorectal Cancer Cells"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-8026","authenticated-orcid":false,"given":"Fei","family":"Tu","sequence":"first","affiliation":[{"name":"School of Forensic Medicine Xinxiang Medical University Xinxiang Henan China"},{"name":"Xinxiang Engineering Technology 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