{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:13:50Z","timestamp":1790079230574,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Silica\u2010induced pulmonary fibrosis is a debilitating condition with limited therapeutic options. Allicin, a bioactive compound derived from garlic, has shown potential anti\u2010inflammatory and antifibrotic properties. However, its role in silica\u2010induced pulmonary fibrosis remains unexplored. Human lung epithelial cells (BEAS\u20102B) and alveolar epithelial cells (A549) were exposed to silica particles, followed by allicin treatment. In vivo experiments, a murine model of silica\u2010induced pulmonary fibrosis was established, and lentiviral tracheal instillation was employed to validate the impact of Serpinb2 knockdown on fibrotic progression. Fibrosis and ferroptosis markers, including GSH\/GSSG, MDA and hydroxyproline content, were assessed. Molecular mechanisms were evaluated using Western blot, RT\u2010PCR, and Immunofluorescence to analyze Serpinb2 expression and NF\u2010\u03baB pathway activation. Allicin can alleviate ferroptosis and pulmonary fibrosis induced by silica. In addition, Serpinb2 is upregulated under the induction of silicon dioxide. Inhibiting Serpinb2 can alleviate ferroptosis and pulmonary fibrosis induced by silicon dioxide. Meanwhile, the addition of allicin can inhibit Serpinb2 and thereby exert the same effect. NF\u2010\u03baB functions as a downstream pathway of Serpinb2. The addition of allicin can inhibit Serpinb2 and thereby suppress the NF\u2010\u03baB pathway, thereby exerting its inhibitory effect on ferroptosis and pulmonary fibrosis. This study demonstrates that allicin attenuates silica\u2010induced pulmonary fibrosis by modulating Serpinb2\/NF\u2010\u03baB pathway via inhibiting ferroptosis. These results highlight the therapeutic potential of allicin in treating pulmonary fibrosis and provide a novel mechanistic insight into its antifibrotic effects.<\/jats:p>","DOI":"10.1002\/jbt.71019","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:18:40Z","timestamp":1783930720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allicin Attenuates Silica\u2010Induced Pulmonary Fibrosis by Targeting the Serpinb2\/NF\u2010\u03baB Pathway"],"prefix":"10.1002","volume":"40","author":[{"given":"Zhou","family":"Sijing","sequence":"first","affiliation":[{"name":"Department of Occupational Disease, The Third People's Hospital of Hefei Hefei Third Clinical College of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Jiling","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The 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