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SDCBP stimulated the proliferation and tumor formation and may be a target for ESCC. However, the participation of SDCBP in epithelial\u2013mesenchymal transition (EMT) and ESCC metastasis is unclear. In this study, we found that SDCBP promoted the EMT process of ESCC cells and facilitated ESCC metastasis both in vitro and in vivo. Mechanically, SDCBP was found to influence the activation of the Wnt\u2010\u03b2\u2010catenin pathway. \u03b2\u2010catenin expression and nuclear localization were regulated by SDCBP, accompanied by altered expression of Wnt\u2010\u03b2\u2010catenin pathway target genes. Additionally, SDCBP interacted with Y\u2010box binding protein 1 (YBX1) and abnormally upregulated YBX1 in ESCC was responsible for SDCBP\u2010mediated regulation of ESCC migration and invasion. Finally, SDCBP was identified to be transcriptionally regulated by the Wnt\u2010\u03b2\u2010catenin pathway. Thus, our study provides a better understanding of the SDCBP\u2010YBX1\u2010Wnt\u2010\u03b2\u2010catenin axis in ESCC metastasis and explores a positive feedback loop between SDCBP and the Wnt\u2010\u03b2\u2010catenin pathway, offering more compelling evidence for employing SDCBP as a target for ESCC treatment.<\/jats:p>","DOI":"10.1002\/jbt.71046","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:26:43Z","timestamp":1785238003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SDCBP Cooperates With YBX1 to Promote ESCC Metastasis by Forming a Positive Feedback Loop With Wnt\u2010\u03b2\u2010Catenin Signaling Pathway"],"prefix":"10.1002","volume":"40","author":[{"given":"Ruijuan","family":"Du","sequence":"first","affiliation":[{"name":"Zhang Zhongjing School of Chinese Medicine, Nanyang Institute of Technology Nanyang China"},{"name":"Henan Key Laboratory of Zhang Zhongjing 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