{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:25:54Z","timestamp":1786951554648,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fine particulate matter (PM\n                    <jats:sub>2.5<\/jats:sub>\n                    ) has a damaging effect on the male reproductive system. Baicalin has excellent anti\u2010inflammatory and antioxidant pharmacological functions. The main purpose of this study was to investigate whether baicalin had a protective effect against PM\n                    <jats:sub>2.5<\/jats:sub>\n                    \u2010induced damage to the reproductive system of mice, and to further investigate the mechanism of the protective effect of baicalin. In our experiment, baicalin was administered by gavage 1\u2009h before PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure, followed by exposure to PM\n                    <jats:sub>2.5<\/jats:sub>\n                    with an oral\u2010nasal exposure system at 750\u2009\u03bcg\/m\n                    <jats:sup>3<\/jats:sup>\n                    for 4\u2009h\/day, and this experiment was continued for 45 days until the model was established. The results indicated that PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure decreased testicular weight and organ coefficient, sperm count, and serum testosterone level, and down\u2010regulated the mRNA and protein expressions of StAR, CYP11A1, and CYP17A1, which related to testosterone synthesis. After baicalin treatment, our experimental results showed that the 50 and 100\u2009mg\/kg baicalin groups showed a gradual increase in sperm counts, testosterone levels, and a significant restoration of genes and protein related to testosterone synthesis and the DKK1\u2010Wnt\/\u03b2\u2010catenin signaling pathway. In conclusion, baicalin might play a protective role in promoting testicular tissue repair, and this may be associated with the regulation of the DKK1 \u2010 Wnt\/\u03b2\u2010catenin signaling pathway.\n                  <\/jats:p>","DOI":"10.1002\/jbt.71057","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:26:55Z","timestamp":1785781615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baicalin Protects Mouse Testis From Injury Induced by PM\n                    <sub>2.5<\/sub>\n                    Associated With the DKK1\u2010Wnt\/\u03b2\u2010Catenin Signaling Pathway"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-9142","authenticated-orcid":false,"given":"Lili","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Key Laboratory of Environmental Pollution and Microecology Shenyang Medical College Shenyang 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