{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:25:52Z","timestamp":1786951552754,"version":"build-2736575974"},"reference-count":107,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Environmental toxicants (ENVOTOX) have emerged as critical risk factors for congenital malformations (CMFs) in the modern industrial era. Although epidemiological evidence underscores their adverse impact on pregnancy outcomes, the underlying molecular mechanisms remain insufficiently defined. This review consolidates current insights into exposome toxicity profiling, developmental pathway disruptions, and molecular mapping to identify potential biomarkers and mechanistic links between ENVOTOX and CMFs. Protein\u2010protein interaction (PPI) network analysis identified 35 CMF\u2010associated proteins, with ten fibroblast growth factors (FGFs: FGF4, FGF5, FGF8, FGF9, FGF10, FGF16, FGF17, FGF18, FGF20, and FGF22) prioritized as hub nodes. Molecular docking analysis showed high binding affinity of FGF9 and FGF4 toward dioxin\u2010associated toxicants, with dibenzo\u2010p\u2010dioxin (DBPDO) exhibiting the strongest interaction (binding energy: \u22127.2\u2009kcal\/mol), followed by polychlorinated dibenzofurans (PCDBFs) (\u22126.7\u2009kcal\/mol) with FGF9. Notably, FGF9 exhibited mutagenic binding potential at ASN146, mediated through \u03c0\u2010donor hydrogen bonding with DBPDO. Comparative toxicity data further highlighted the acute risks, as DBPDO demonstrated a lower LD\n                    <jats:sub>50<\/jats:sub>\n                    (2.26\u2009mol\/kg) relative to PCDBFs (4.134\u2009mol\/kg). Collectively, this review emphasizes the central role of FGFs in mediating ENVOTOX\u2010induced teratogenicity and offers molecular\u2010level perspectives to guide biomarker discovery and intervention strategies for mitigating CMF risk.\n                  <\/jats:p>","DOI":"10.1002\/jbt.71067","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:03:46Z","timestamp":1786359826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-669X","authenticated-orcid":false,"given":"Adarsh Kumar","family":"Shukla","sequence":"first","affiliation":[{"name":"Multidisciplinary Research Unit Dr. Bhimrao Ramji Ambedkar Government Medical College Kannauj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-723X","authenticated-orcid":false,"given":"Rashmi","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit Dr. Bhimrao Ramji Ambedkar Government Medical College Kannauj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj Kumar","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit Dr. Bhimrao Ramji Ambedkar Government Medical College Kannauj India"},{"name":"Department of Microbiology Dr. Bhimrao Ramji Ambedkar Government Medical College Kannauj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamendra","family":"Swaroop","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit Dr. Bhimrao Ramji Ambedkar Government Medical College Kannauj India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2025.108940"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40697-8_6"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0212-7"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2249"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.17749\/2313-7347\/ob.gyn.rep.2024.487"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21137"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2016.1211090"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2016-0112"},{"key":"e_1_2_20_10_1","first-page":"17","article-title":"The Decade of Fractogene: From Discovery to Utility \u2010 Proofs of Concept Open Genome\u2010Based Clinical Applications","volume":"1","author":"Pellionisz A. 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