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Transfer RNA\u2010derived small RNAs (tsRNAs) have been recognized as pivotal regulators in oncogenic processes. In this study, we identified a specific tsRNA associated with non\u2010invasive lung adenocarcinoma and demonstrated its suppressive effects on cellular proliferation and metastatic potential. At the molecular level, this tsRNA exerts its regulatory function by targeting and repressing G6PD mRNA, thereby perturbing the equilibrium between NADPH and reactive oxygen species (ROS) production. This discovery positions the identified tsRNA as a promising candidate for therapeutic intervention in non\u2010invasive lung adenocarcinoma. Further investigation into the role of tsRNAs in lung adenocarcinoma is imperative to fully harness their potential in clinical management.<\/jats:p>","DOI":"10.1002\/jbt.71077","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:34:40Z","timestamp":1788338080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A tsRNA Suppresses Lung Adenocarcinoma Progression Through Targeting Glucose\u20106\u2010Phosphate Dehydrogenase"],"prefix":"10.1002","volume":"40","author":[{"given":"Suo","family":"Sha","sequence":"first","affiliation":[{"name":"Surgery of Traditional Chinese Medicine, Hai'an Hospital of Traditional Chinese Medicine Hai'an, Nantong Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Hai'an City People's Hospital of Jiangsu 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