{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:08:23Z","timestamp":1789549703334,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Prostate cancer (PCa) remains a leading cause of cancer\u2010related mortality in aging male, with resistance to enzalutamide (Enza) representing a major therapeutic challenge. This study identifies SLC3A1 as a key driver of Enza resistance. Through integrative bioinformatics analysis of GEO datasets, we found\n                    <jats:italic>SLC3A1<\/jats:italic>\n                    significantly upregulated in Enza\u2010resistant PCa models. WGCNA and single\u2010cell RNA sequencing confirmed its association with adverse prognosis and activation of key survival pathways. Functional experiments demonstrated that\n                    <jats:italic>SLC3A1<\/jats:italic>\n                    knockdown reduced AKT phosphorylation, and inhibited colony formation in LNCaP cells. Conversely,\n                    <jats:italic>SLC3A1<\/jats:italic>\n                    overexpression activated PI3K\u2010AKT signaling, suppressed ferroptosis and conferred Enza resistance in vitro and in vivo. These results reveal SLC3A1 is a promising therapeutic target for advanced prostate cancer.\n                  <\/jats:p>","DOI":"10.1002\/jbt.71080","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:12:20Z","timestamp":1786979540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SLC3A1 Mitigates Ferroptosis and Promotes Enzalutamide Resistance in Prostate Cancer"],"prefix":"10.1002","volume":"40","author":[{"given":"Peng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology 411 Hospital of Shanghai University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology 411 Hospital of Shanghai University Shanghai 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