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Luteolin, a naturally occurring flavonoid abundant in various medicinal plants, exhibits well\u2010documented antioxidant and anticancer activities. This study investigated whether Luteolin isolated from\n                    <jats:italic>Pistacia terebinthus<\/jats:italic>\n                    fruits could attenuate Cisplatin\u2010induced organ toxicity while enhancing its antiproliferative effects. For the in vivo experiments, 48 male Swiss albino mice (9\u201310 weeks old, 26\u201330\u2009g) were randomly assigned to eight groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096\/group): control, Cisplatin, Luteolin (25, 50, or 100\u2009mg\/kg), and Cisplatin plus Luteolin (25, 50, or 100\u2009mg\/kg). Cisplatin (10\u2009mg\/kg\/day, intraperitoneally) and\/or Luteolin (25\u2013100\u2009mg\/kg\/day, orally) were administered for 14 consecutive days. Serum biochemical parameters, oxidative stress markers, antioxidant enzyme activities, and tissue injury\u2010related biomarkers were evaluated in liver and kidney tissues. Cisplatin administration significantly increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and glucose levels, whereas co\u2010treatment with Luteolin markedly attenuated these alterations in a dose\u2010dependent manner. In addition, Luteolin restored Cisplatin\u2010induced disturbances in oxidative stress and antioxidant defense markers, including malondialdehyde (MDA), 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8\u2010OHdG), HSP70 levels, superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione S\u2010transferase (GST) activities in liver and kidney tissues. To support the in vivo findings, in vitro antiproliferative assays were performed using Saos\u20102 osteosarcoma, HTB\u20109 bladder cancer, A549 lung cancer, and BEAS\u20102B normal epithelial cell lines. Cells were treated with Luteolin (5\u2013200\u2009\u00b5M) alone or in combination with Cisplatin IC50 concentrations for 24\u201348\u2009h, and cell viability was assessed using the WST\u20101 assay. Co\u2010treatment with Luteolin significantly enhanced Cisplatin\u2010induced growth inhibition in cancer cells while exerting limited cytotoxicity in normal cells. Luteolin alone also demonstrated concentration\u2010dependent antiproliferative activity. In conclusion, Luteolin exerted marked hepatorenal protective effects and enhanced the antiproliferative activity of Cisplatin in experimental models. These findings suggest that Luteolin may represent a promising adjunctive candidate for reducing Cisplatin\u2010associated toxicity while improving therapeutic responsiveness.\n                  <\/jats:p>","DOI":"10.1002\/jbt.71100","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:07:21Z","timestamp":1788181641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of Luteolin Against Cisplatin\u2010Induced Hepatic and Renal Toxicity: Biochemical and Cellular Evidence"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0668-5744","authenticated-orcid":false,"given":"\u00d6zge","family":"Temiz","sequence":"first","affiliation":[{"name":"Vocational School of Health Services Osmaniye Korkut Ata University Osmaniye 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