{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:08:21Z","timestamp":1789549701329,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>BDNF and its receptor, TrkB, are essential regulators of energy homeostasis in both central and peripheral tissues, including the liver. This study aimed to investigate the effects of ANA\u201012, a selective TrkB antagonist, on hepatic mitochondrial enzyme activities and biochemical parameters in a mouse model of sucrose\u2010induced insulin resistance. Male C57BL\/6J mice were divided into four groups: Control, Sucrose (35% solution), Sucrose+DMSO, and Sucrose+ANA\u201012 (0.5\u2009mg\/kg). Following a 16\u2010week dietary intervention, ANA\u201012 was administered via intraperitoneal injection during the final 21\u2009days. Hepatic activities of cytochrome c oxidase, superoxide dismutase (SOD), and catalase (CAT), along with malondialdehyde (MDA) levels, were analyzed to evaluate mitochondrial enzyme activity and oxidative stress\u2010related biochemical changes. Chronic sucrose consumption significantly increased body weight, serum insulin levels, HOMA\u2010IR scores, and cholesterol levels. While ANA\u201012 treatment showed a numerical tendency to attenuate weight gain and HOMA\u2010IR scores, these changes did not reach statistical significance. However, the ANA\u201012 group exhibited significantly lower serum leptin and ceramide levels compared to the Sucrose+DMSO group. In the liver, sucrose consumption triggered oxidative stress, as evidenced by increased MDA levels. Conversely, TrkB inhibition was associated with increased cytochrome c oxidase activity, altered SOD activity, and reduced hepatic MDA concentrations compared with the Sucrose+DMSO group, suggesting partial modulation of oxidative stress\u2010related biochemical alterations. Furthermore, chronic sucrose consumption was associated with reduced hepatic BDNF levels. Overall, these findings indicate that TrkB inhibition may influence selected hepatic mitochondrial enzyme activities and redox\u2010related markers under sucrose\u2010induced metabolic stress. However, these results should be interpreted cautiously because systemic insulin resistance markers were not significantly improved, and additional control groups are required to clarify ANA\u201012\u2010specific and vehicle\u2010related effects.<\/jats:p>","DOI":"10.1002\/jbt.71104","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:13:41Z","timestamp":1788171221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of Tropomyosin Receptor Kinase B Signaling Alters Hepatic Mitochondrial Enzyme Activity and Oxidative Stress in Mice With Sucrose\u2010Induced Insulin Resistance"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-2717","authenticated-orcid":false,"given":"Ak\u0131n","family":"Bodur","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences Kahramanmara\u015f 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