{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:34:03Z","timestamp":1792956843518,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of 1\u2010(4\u2010Chorophenyl)\u20103Aryl\u20101\u2010\n                    <jats:italic>H<\/jats:italic>\n                    \u2010pyrazole\u20104\u2010carbaldehyde derivatives were synthesized under the microwave irradiation (MW) technique. IR,\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR, and mass spectroscopic techniques were used to confirm the structure of the synthesized compounds. The newly synthesized Pyrazole aldehydes were evaluated for their in vitro anti\u2010inflammatory and anti\u2010tubercular activity. Among them, the compounds\n                    <jats:bold>4c<\/jats:bold>\n                    and\n                    <jats:bold>4e<\/jats:bold>\n                    exhibited significant reduction of LPS\u2010induced COX\u20102 protein levels across all tested concentrations. Whereas compounds\n                    <jats:bold>4f<\/jats:bold>\n                    and\n                    <jats:bold>4j<\/jats:bold>\n                    exhibited sensitivity to tuberculosis at the lowest concentration of 6.25\u2009\u00b5g\/mL, which was comparable to that of the standard drug pyrazinamide. Molecular docking against the Crystal structure of diclofenac bound to the cyclooxygenase active site of COX\u20102 (PDB ID: 5KIR) also supports the experimental results. The molecular docking studies have demonstrated their better\u2010fit potential as anti\u2010inflammatory agents.\n                  <\/jats:p>","DOI":"10.1002\/jbt.71113","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:39:11Z","timestamp":1789652351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Pyrazole\u20104\u2010Carbaldehyde Derivatives Having Potent COX\u20102 Inhibition and Anti\u2010Tubercular Activity: Microwave\u2010Assisted Green Synthesis and Molecular Docking"],"prefix":"10.1002","volume":"40","author":[{"given":"Megha","family":"Kokane","sequence":"first","affiliation":[{"name":"School of Chemical Sciences Punyashlok Ahilyadevi Holkar Solapur University Solapur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6955-4433","authenticated-orcid":false,"given":"Dnyandev","family":"Bhosale","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences Punyashlok Ahilyadevi Holkar Solapur University Solapur Maharashtra India"},{"name":"Department of Chemistry Pratapsinh Mohite\u2010Patil Mahavidyalaya Karmala Solapur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2684-3383","authenticated-orcid":false,"given":"Dattatraya","family":"Raut","sequence":"additional","affiliation":[{"name":"Vishwasrao Naik Arts Commerce, and Baba Naik Science Mahavidyalaya, Shirala District\u2010Sangli Maharashtra state India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7231-3347","authenticated-orcid":false,"given":"Pushpa","family":"Hadimani","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences Punyashlok Ahilyadevi Holkar Solapur University Solapur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Narale","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences Punyashlok Ahilyadevi Holkar Solapur University Solapur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-3982","authenticated-orcid":false,"given":"Prafulla","family":"Choudhari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Bharati Vidyapeeth College of Pharmacy Kolhapur Maharashtra state India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3388-0625","authenticated-orcid":false,"given":"Anjana","family":"Lawand","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences Punyashlok Ahilyadevi Holkar Solapur University Solapur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130554"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2014.12.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA00928E"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA06478E"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.60.110"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.10.028"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2012.04.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2015.07.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23010134"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c07267"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-024-03335-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0223-5234(02)01388-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.06.046"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA05257A"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301145"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140919"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA14531K"},{"key":"e_1_2_9_20_1","unstructured":"P. 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