{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:33:56Z","timestamp":1792956836533,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["UGC\/BSR faculty fellowship No. f.4\u2010(11)2019 (BSR)"],"award-info":[{"award-number":["UGC\/BSR faculty fellowship No. f.4\u2010(11)2019 (BSR)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In order to investigate their possible biological activity, a number of new Schiff base compounds based on diaryl ether, specifically 2\u2010(substituted\u2010arylamino)\u2010N\u2032\u2010(3\u2010phenoxybenzylidene) acetohydrazides, were created. IR,\n                    <jats:sup>1<\/jats:sup>\n                    H NMR, and\n                    <jats:sup>13<\/jats:sup>\n                    C NMR spectrum studies were used to characterize all substances. A structure\u2013activity link influenced by the kind of substituents on the aryl moiety was suggested by the evaluation of the synthesized derivatives\u2019 in vitro biological activity, which showed significant activity patterns among substituted analogs. Molecular docking studies demonstrated favorable binding interactions of the most active compounds with the selected biological target, supported by key hydrogen bonding and hydrophobic interactions within the active site. Furthermore, molecular dynamics simulations confirmed the stability of the ligand\u2013protein complexes, indicating their potential as promising lead molecules. The novelty of this study lies in the design of hybrid diaryl ether\u2013Schiff base derivatives and their combined experimental and computational evaluation, providing insights into their biological potential and guiding future optimization.\n                  <\/jats:p>","DOI":"10.1002\/jbt.71114","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:26:00Z","timestamp":1790187960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biological Evaluation, Molecular Docking, MD Simulation Study and Synthesis of (Z)\u2010N\u2019\u2010(3\u2010phenoxybenzylidene)\u20102\u2010(substituted\u2010amino aryl) Acetohydrazid"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8112-3181","authenticated-orcid":false,"given":"Navin B.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Chemistry, Organic Research Laboratory Veer Narmad South Gujarat University Surat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti S.","family":"Ghaisas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Organic Research Laboratory Veer Narmad South Gujarat University Surat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2286-1915","authenticated-orcid":false,"given":"Vatsal M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Chemistry C. 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Mangalam University Gurugram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Imran","sequence":"additional","affiliation":[{"name":"Center for Health Research Northern Border University Arar Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9842-4167","authenticated-orcid":false,"given":"Gildardo","family":"Rivera","sequence":"additional","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda Farmac\u00e9utica Centro de Biotecnolog\u00eda Gen\u00f3mica, Instituto Polit\u00e9cnico Nacional Reynosa Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7491-6706","authenticated-orcid":false,"given":"Hetal I.","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Chemistry C. B. Patel Computer College &amp; J. N. M. 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