{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:40Z","timestamp":1789609120416,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,10,14]],"date-time":"2003-10-14T00:00:00Z","timestamp":1066089600000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although it is known that LDL\u2010apheresis improves ischemic limb seen in patients with peripheral arterial occlusive disease (PAOD), the underlying mechanism(s) still remains unknown. We studied whether vascular endothelial growth factor (VEGF) and\/or insulin\u2010like growth factor\u2010I (IGF\u2010I) levels correlated with improvement of ischemic limbs after LDL\u2010apheresis. Sixteen patients with PAOD (13 men, 3 women) were enrolled in our study. LDL\u2010apheresis was performed 10 times (treated plasma 3,000 ml) for 5 weeks. Serum level of VEGF significantly increased from 262 \u00b1 171 pg\/ml to 306 \u00b1 165 pg\/ml before and after LDL\u2010apheresis (<jats:italic>P<\/jats:italic> &lt; 0.05). This value further increased up to 441 \u00b1 175 pg\/ml 3 months after the end of this therapy (<jats:italic>P<\/jats:italic> &lt; 0.01, compared with the basal value and <jats:italic>P<\/jats:italic> &lt; 0.05, compared with the value at the end of 10\u2010times session). Increased levels of VEGF paralleled increases in the ankle\u2010brachial pressure index (ABI). After 10\u2010times therapy, IGF\u2010I significantly decreased (<jats:italic>P<\/jats:italic> &lt; 0.05), but increased over the basal value 3 months after this therapy. Plasma fibrinogen statistically decreased and remained low for 3 months. The favorable effects of LDL\u2010apheresis may be ascribed to up\u2010regulation of VEGF and IGF\u2010I associated with decreased fibrinogen levels. J. Clin. Apheresis, 18:115\u2013119, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jca.10055","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T12:00:33Z","timestamp":1066392033000},"page":"115-119","source":"Crossref","is-referenced-by-count":49,"title":["LDL\u2010apheresis up\u2010regulates VEGF and IGF\u2010I in patients with ischemic limb"],"prefix":"10.1002","volume":"18","author":[{"given":"Shuzo","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyouko","family":"Maesato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayasu","family":"Ohtake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260605"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.5.6.613"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90811-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.43.6.680"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(85)90022-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002216-198907000-00057"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979304400308"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.10.1826"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000045113"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979804900302"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979204300710"},{"key":"e_1_2_1_13_2","first-page":"336","article-title":"Effect 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