{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T15:50:10Z","timestamp":1722441010548},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,12,24]],"date-time":"2003-12-24T00:00:00Z","timestamp":1072224000000},"content-version":"vor","delay-in-days":357,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracorporeal double filtration plasmapheresis (EDFP) can quickly lower plasma viscosity and fibrinogen concentration. EDFP has the potential to improve cerebral microcirculation in acute ischemic stroke and ultimately to salvage penumbral tissue. However, no evidence is available to show that EDFP can increase cerebra blood flow (CBF). Therefore, we investigated whether EDFP could increase CBF by quantitative CBF measurements and documented the clinical effects of EDFP in acute ischemic stroke. EDFP was performed ten times in seven patients diagnosed as having acute atherothrombotic brain infarction caused by major artery occlusive lesion. They also fulfilled one of the following entry criteria: 1) diffusion\/perfusion mismatch demonstrated by MRI on admission; 2) a hemispheric syndrome, but only a small lesion on diffusion weighted MRI (&lt;25% of MCA territory); or 3) progressing stroke. Exclusion criteria were 1) contraindication of heparin or 2) spontaneous improvement of symptoms. Time from stroke onset to EDFP varied from 5 hr to 7 days. Plasma viscosity was quickly lowered by EDFP without affecting RBC counts, Hb, or Hct in all patients. Positron emission tomography (PET) with 15\u2010O labeled H<jats:sub>2<\/jats:sub>O measurements revealed a significant CBF increase from 36.4\u00b18.3 ml\/100 g\/min to 40.7\u00b16.8 ml\/100 g\/min in the affected hemisphere (<jats:italic>P<\/jats:italic>=0.048). Definite CBF improvement was also demonstrated by single photon emission computed tomography (SPECT) in one of two patients who had severe stenosis of the middle cerebral artery. Furthermore, this patient showed remarkable improvement of hemiplegia immediately following EDFP (NIHSS score: 18 to 13). In conclusion, EDFP can increase CBF in ischemic brain tissue in acute atherothrombotic brain infarction. Further clinical studies should focus on the efficacy of EDFP on outcome of patients with this stroke subtype. J. Clin. Apheresis 18:167\u2013174, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jca.10064","type":"journal-article","created":{"date-parts":[[2003,12,25]],"date-time":"2003-12-25T09:01:23Z","timestamp":1072342883000},"page":"167-174","source":"Crossref","is-referenced-by-count":4,"title":["Extracorporeal double filtration plasmapheresis in acute atherothrombotic brain infarction caused by major artery occlusive lesion"],"prefix":"10.1002","volume":"18","author":[{"given":"Yasuhiro","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Tagaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takenori","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Minematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.1.157"},{"key":"e_1_2_1_3_2","first-page":"377","volume-title":"Stroke: pathophysiology, diagnosis, and management, vol 1","author":"Mohr JP","year":"1986"},{"key":"e_1_2_1_4_2","first-page":"353","volume-title":"Handbook of clinical neurology, vol 9(53). Vascular disease part I","author":"Kase CS","year":"1988"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/jama.1995.03530130023023","article-title":"Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: the European Cooperative Acute Stroke Study (ECASS)","volume":"274","author":"<!?twb=.45w>Hacke W","year":"1995","journal-title":"JAMA"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-68459-6_27"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.2.8668784"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410506"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.29"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.16.1298"},{"key":"e_1_2_1_12_2","series-title":"Stroke","first-page":"97","author":"Wood JH","year":"1986"},{"key":"e_1_2_1_13_2","first-page":"318","article-title":"Haemodilution in acute stroke: results of the Italian haemodilution trial","volume":"1","author":"Italian Acute Stroke Study Group","year":"1988","journal-title":"Lancet"},{"key":"e_1_2_1_14_2","first-page":"530","article-title":"Multicenter trial of hemodilution in acute ischemic stroke","volume":"73","author":"Asplund K","year":"1986","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.3.317"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.6.980"},{"key":"e_1_2_1_17_2","first-page":"464","article-title":"Multicenter trial of hemodilution in ischemic stroke, II: subgroup analyses","volume":"119","author":"Scandinavian Stroke Study Group","year":"1998","journal-title":"Stroke"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb00621.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.4.787"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90090-6"},{"key":"e_1_2_1_21_2","first-page":"81","article-title":"Heparin\u2010mediated extracorporeal LDL\/fibrinogen precipitation\u2014H.E.L.P.\u2014in coronary and cerebral ischemia","volume":"73","author":"Jaeger BR","year":"1999","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.8.1056"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.7.1383"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.89"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200009000-00002"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200006000-00007"},{"key":"e_1_2_1_27_2","first-page":"H1190","article-title":"Hemodilution, cerebral O2 delivery, and cerebral blood flow: a study using hyperbaric oxygenation","volume":"276","author":"Tomiyama Y","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.18.2395"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.8.1328"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.9.1802"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.10064","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.10064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:54:48Z","timestamp":1700250888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.10064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/jca.10064"],"URL":"https:\/\/doi.org\/10.1002\/jca.10064","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}