{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T20:40:06Z","timestamp":1700253606675},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,10,14]],"date-time":"2003-10-14T00:00:00Z","timestamp":1066089600000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Modern blood separators rapidly process many liters of donor blood and efficiently collect vast quantities of blood components from donors, who may be stimulated with potent recombinant hematopoietic growth factors or cytokines. Accordingly, the potential risks of modern multiple product\/unit apheresis donations and recombinant growth factors is analyzed in this report. As is true for all medical procedures, risks are associated with apheresis donations. Risks of a \u201cstandard\u201d apheresis donation, in which one unit of PLTs or plasma is collected, are comparable to the risks of whole blood donation. Risks of multiple unit apheresis donations, in which either vast quantities of a single blood component or multiple units of various components are collected, are incompletely understood, particularly, when donors are stimulated with recombinant hematopoietic growth factors to increase component yields. To minimize donor risks and to increase knowledge of multiple component apheresis donations, both short\u2010term problems (e.g., donor reactions accompanying apheresis procedures and pre\u2010 vs. post\u2010procedure changes in results of donor laboratory studies) and long\u2010term problems (e.g., medical diagnoses\/problems and abnormalities of donor blood counts and laboratory test results) should be monitored, ideally, by a repeat donor registry. When recombinant hematopoietic growth factors are prescribed, donors should give informed consent, and blood center professionals must be aware of 1) the effects of these drugs given at pharmacologic, rather than physiologic, doses; 2) the differences between the molecular structure of recombinant vs. natural\/endogenous growth factors; 3) the fact that recombinant growth factors have both narrow\/focused and broad biological activities; and 4) the probability that results of studies in sick\/immunosuppressed patients may not be applicable to healthy\/immunocompetent donors. J. Clin. Apheresis 18:135\u2013140, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jca.10069","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T12:00:33Z","timestamp":1066392033000},"page":"135-140","source":"Crossref","is-referenced-by-count":6,"title":["Safety of donating multiple products in a single apheresis collection: Are we expecting too much?"],"prefix":"10.1002","volume":"18","author":[{"given":"Ronald 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