{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:10:11Z","timestamp":1700410211768},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,10,5]],"date-time":"2001-10-05T00:00:00Z","timestamp":1002240000000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Modern cell separators allow the collection of two plateletpheresis concentrates (PCs) at one session. This study evaluates the quality of PCs stored as double concentrates in standard storage containers of two manufacturers. We collected 20 PCs that contained 4.5 \u00d7 10<jats:sup>11<\/jats:sup> platelets in 375 ml plasma (10 using the COBE Spectra and 10 using the Fresenius AS.TEC 204 with 500 ml bags) that were split into one unit of 3.0 \u00d7 10<jats:sup>11<\/jats:sup> platelets in 250 ml (3.0\u2010PC) and one of 1.5 \u00d7 10<jats:sup>11<\/jats:sup> platelets in 125 ml (1.5\u2010PC). Storage of one 3.0\u2010PC per bag of a two\u2010bag system corresponded to storage conditions for double PCs and storage of one 1.5\u2010PC per bag to storage conditions of single PCs. Cell counts, blood gas analysis, glucose and lactate levels, platelet aggregation, and activation and plasma levels of \u03b2\u2010 thromboglobulin (\u03b2\u2010TG) and complement factor 3a (C3a) were measured before storage and again on days 3 and 5. COBE 3.0\u2010PCs demonstrated less pH rise, lactate production, CD 62P expression and \u03b2\u2010TG plasma levels, and better aggregability after storage than COBE 1.5\u2010PCs. Fresenius 1.5\u2010PCs had similar platelet quality to COBE 3.0\u2010PCs. Fresenius 3.0\u2010PCs showed a fall of pH (day 5: 6.22 \u00b1 0.56), the highest amount of anaerobic glycolysis compared to all other storage conditions investigated, high CD 62P\u2010 expression and \u03b2\u2010TG plasma levels, and impaired aggregability on days 3 and 5. The highest C3a levels were found in COBE 1.5\u2010PCs. 3.0 \u00d7 10<jats:sup>11<\/jats:sup> platelets in 250 ml plasma should be stored either in one bag of the COBE system or in two 500 ml bags of the Fresenius system. The COBE two\u2010bag system allows the storage of two PCs without loss of platelet quality. Two PCs should not be stored in the Fresenius C4L 500 ml storage containers. J. Clin. Apheresis. 16:148\u2010154, 2000. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jca.1028","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:50:10Z","timestamp":1030305010000},"page":"148-154","source":"Crossref","is-referenced-by-count":4,"title":["Storage of single donor platelet concentrates: Paired comparison of storage as single or double 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