{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:15:04Z","timestamp":1770822904212,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T00:00:00Z","timestamp":1090195200000},"content-version":"vor","delay-in-days":200,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The supply of deceased donor kidneys is inadequate to meet demand. To expand the pool of potential donors, ABO\u2010incompatible transplants from living donors have been performed. We present the Mayo Clinic experience with such transplants. Enrollment was open to patients when the only available potential living kidney donor was ABO\u2010incompatible. Conditioning consisted of plasma exchanges followed by intravenous immunoglobulin. Splenectomy was performed at the time of transplant surgery. Post\u2010transplant immunosuppression consisted of anti\u2010T lymphocyte antibody, tacrolimus, mycophenolate mofetil, and prednisone. Isoagglutinin titers and scores were determined before and after each plasma exchange. Transplant outcomes were determined. Twenty\u2010six ABO\u2010incompatible transplants were performed. No hyperacute rejection occurred. Mean patient follow\u2010up was 400 days. Patient and graft survivals at last follow\u2010up were 92 and 85%, respectively. Antibody\u2010mediated rejection occurred in 46% and was apparently reversed in 83% by plasma exchange and increased immunosuppression. The initial plasma exchange reduced immediate spin and AHG hemagglutination reactivity scores by 53.5 and 34.6%, respectively. Over the course of the pretransplant plasma exchanges, the immediate spin and AHG hemagglutination reactivity scores decreased by 96.4 and 68.5%, respectively. At 3 and 12 months, the immediate spin and AHG hemagglutinin reactivity scores and titers were less than those at baseline but greater than or equal to those on the day of transplantation. Despite an increase in scores and titers, antibody\u2010mediated rejection was not present. Pre\u2010transplant plasma exchange conditioning combined with other immunosuppressives can be used to prepare patients for ABO\u2010incompatible kidney transplantation from living donors, but antibody\u2010mediated rejection post\u2010transplant is a common occurrence and allograft survival may be reduced. Controlled clinical trials are needed to identify the optimum conditioning for ABO\u2010incompatible renal transplants. J. Clin. Apheresis 19:79\u201385, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jca.20002","type":"journal-article","created":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T21:01:39Z","timestamp":1090270899000},"page":"79-85","source":"Crossref","is-referenced-by-count":60,"title":["Plasma exchange conditioning for ABO\u2010incompatible renal transplantation"],"prefix":"10.1002","volume":"19","author":[{"given":"J.L.","family":"Winters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Gloor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Stegall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.B.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,19]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"United Network for Organ Sharing URRaEA. 2001 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry for Transplant Recipients: Transplant Data 1991\u20132000. Rockville MD Richmond VA Ann Arbor MI: Department of Health and Human Services Health Resources and Services Administration Office of Special Programs Division of Transplantation;2001."},{"key":"e_1_2_1_3_2","first-page":"4549","article-title":"ABO incompatibility in cadaver donor kidney allografts","volume":"19","author":"Cook DJ","year":"1987","journal-title":"Transplant Proc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000058226.39732.32"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199801270-00014"},{"key":"e_1_2_1_6_2","unstructured":"2002 American Association of Blood Banks Bethesda MD ME Brecher Technical manual 14th ed"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1972.tb04459.x"},{"key":"e_1_2_1_8_2","first-page":"1","article-title":"Histologic findings of antibody mediated rejection in ABO blood group incompatible living donor kidney transplantation","volume":"3","author":"Fidler ME","year":"2003","journal-title":"Am J Transplant"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2001.00313.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2001.00321.x"},{"key":"e_1_2_1_11_2","first-page":"346","article-title":"The efficacy of plasma exchange in the removal of plasma components","volume":"104","author":"Derksen RH","year":"1984","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","first-page":"12","volume-title":"Therapeutic hemapheresis","author":"Chopek M","year":"1980"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V56.6.1055.1055"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00180.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20809.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199402270-00014"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200009270-00006"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(90)90174-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0297-196"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/2063"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.6.4185"},{"key":"e_1_2_1_22_2","first-page":"4538","article-title":"Present experience in a series of 26 ABO\u2010incompatible living donor renal allografts","volume":"19","author":"Alexandre GPJ","year":"1987","journal-title":"Transplant Proc"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00179.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_1_25_2","unstructured":"2002 Annual report of the U.S. Organ Procurement and transplantation network and the scientific registry of transplant recipients: transplant data 1992\u20132001. 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