{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:03Z","timestamp":1786977963210,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,8,30]],"date-time":"2010-08-30T00:00:00Z","timestamp":1283126400000},"content-version":"vor","delay-in-days":241,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Elevated Lipoprotein (a) (Lp(a)) levels are associated with atherosclerosis and are independent risk factors for coronary artery disease and stroke [Ariyo et al., N Engl J Med 2003;349:2108\u20132115; Price et al., Atherosclerosis 2001;157:241\u2013249]. Low\u2010density lipoprotein (LDL)\u2010apheresis is the most effective therapy for reducing Lp(a) levels [Parker, Chem Phys Lipids 1994;67\u201368:331\u2013338; Stefanutti et al., Transfus Apher Sci 2010;42:21\u201326]. Dextran sulfate\u2010cellulose adsorption (Liposorber\u00ae) removes both LDL and Lp(a) particles with minimal effect on high\u2010density lipoprotein levels. During the procedure, high levels of bradykinin are generated as the kallikrein\u2010kinin system is activated by contact with the negatively charged dextran\u2010sulfate cellulose [Krieter et al., Artif Organs 2005;29:47\u201352]. Bradykinin is a potent vasodilator and a substrate of the angiotension converting enzyme (ACE). ACE inhibitors are contraindicated for apheresis procedures because these drugs prevent bradykinin degradation, which causes anaphylatoid reactions characterized by hypotension, bradycardia, dyspnea, and flushing [Owen and Brecher, Transfusion 1994;34:891\u2013894]. Turmeric is a yellow spice that is used as an herbal remedy to treat a myriad of conditions ranging from abdominal pain to pulmonary infections. Scientific investigations of the ethnomedicinal properties of curcumin, the major derivative of turmeric, suggest that this compound has anti\u2010inflammatory, antioxidant, and antineoplastic properties [Lobo et al., J Pharm Pharmacol 2009;61:13\u201321]. We report a case of a patient undergoing Liposorber\u00ae therapy for treatment of hyperLp(a)lipidemia who had three episodes of anaphylactoid\u2010like reactions after starting therapy with the spice turmeric. J. Clin. Apheresis, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jca.20254","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T13:17:37Z","timestamp":1283260657000},"page":"354-357","source":"Crossref","is-referenced-by-count":12,"title":["Anaphylactoid\u2010like reactions in a patient with HyperLp(a)lipidemia undergoing LDL apheresis with dextran sulfate adsorption and herbal therapy with the spice turmeric"],"prefix":"10.1002","volume":"25","author":[{"given":"Jill","family":"Adamski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lita","family":"Jamensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don L.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S.","family":"Sachais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001066"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00719-X"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(94)90154-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2009.10.003"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2004.29007.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.341095026976.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.61.01.0003"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152906779010764"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-27661-0_19"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2004.01.008"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20036"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92673-4"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1407"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(96)00032-4"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-3032-8"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00207-5"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.02.004"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.05.021"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/np900227x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/BA20080041"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.20254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.20254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:46:54Z","timestamp":1696891614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.20254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/jca.20254"],"URL":"https:\/\/doi.org\/10.1002\/jca.20254","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}