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Blood centers have instituted various screening procedures in an effort to determine that donors are free of diseases that can be transmitted to patients by blood transfusion and are able to tolerate the collection procedure without experiencing significant complications. This review focuses on selection criteria intended to minimize the risk to the blood donor. Defining a rational, evidence\u2010based approach to donor selection is crucial not only to take reasonable precautions to protect the donors' health but also to eliminate practices that lead to the unnecessary deferral of large numbers of people without improving the safety of the donation process. Donor selection criteria, including predonation pulse and blood pressure, donor weight and total blood volume, minimum hemoglobin and donation interval, are considered against the available evidence that support or suggest the need to modify the current approach to protect blood donor health. J. Clin. Apheresis, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jca.20257","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T02:17:30Z","timestamp":1283912250000},"page":"331-337","source":"Crossref","is-referenced-by-count":21,"title":["Evidence\u2010based selection criteria to protect blood donors"],"prefix":"10.1002","volume":"25","author":[{"given":"Anne","family":"Eder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,7]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.03.003"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01811.x"},{"key":"e_1_2_4_4_2","unstructured":"Department of Health and Human Services Food and Drug Administration Requirements for Human Blood and Blood Components Intended for Transfusion or for Further Manufacturing Use. Proposed Rule Federal Register: November 8 2007(Volume 72 Number 216) 21 CFR Parts 606 610. Available at:http:\/\/frwebgate.access.gpo.gov\/cgi\u2010bin\/getdoc.cgi?dbname=2007_register&docid=fr08no07\u201026.pdf; Accessed July 31 2010."},{"key":"e_1_2_4_5_2","volume-title":"AABB Standards for Blood Banks and Transfusion Services","author":"Price TH","year":"2009"},{"key":"e_1_2_4_6_2","volume-title":"Guide to the preparation, use and quality assurance of blood components","author":"Council of Europe","year":"2008"},{"key":"e_1_2_4_7_2","unstructured":"Commission Directive 2004\/33\/EC of 22 March 2004 implementing Directive 2002\/98\/EC of the European Parliament and of the Council as regards certain technical requirements for blood and blood components. Official Journal of the European Union. 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