{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:43:08Z","timestamp":1770280988785,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T00:00:00Z","timestamp":1305244800000},"content-version":"vor","delay-in-days":132,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Centro Regional de Hemoterapia de Ribeirao Preto"},{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeirao Preto"},{"name":"Universidade de S\u00e3o Paulo-USP"},{"name":"Ribeirao Preto"},{"name":"Sao Paulo, Brazil","award":["306\/2008"],"award-info":[{"award-number":["306\/2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukostasis is a relatively uncommon but potentially catastrophic complication of acute myelogenous leukemia (AML). Prompt leukoreduction is considered imperative to reduce the high mortality rate in this condition. Leukapheresis, usually associated with chemotherapy, is an established approach to diminish blast cell counts. We report a single center experience in managing leukostasis with leukapheresis. Fifteen patients with leukostasis of 187 patients with AML (8.02%) followed at our institution were treated with leukapheresis associated with chemotherapy. The procedures were scheduled to be performed on a daily basis until clinical improvement was achieved and WBC counts were significantly reduced. Overall and early mortalities, defined as that occurred in the first 7 days from diagnosis, were reported. A high proportion of our patients with leukostasis (46.66%) had a monocytic subtype AML (M4\/M5, according to French\u2010American\u2010British classification). The median overall survival was 10 days, despite a significant WBC reduction after the first apheresis procedure (from 200.7 \u00d7 10<jats:sup>9<\/jats:sup>\/L to 150.3 \u00d7 10<jats:sup>9<\/jats:sup>\/L). Almost half of patients (7\/15) had an early death. Therapeutic leukapheresis, associated or not to chemotherapy, is an effective approach to reduce WBC counts in patients with AML and leukostasis; however, this therapeutic procedure does not appear to change significantly the sombre prognosis observed in the majority of patients with this complication. Other forms of treatment must be found to reduce the high mortality rate related to leukostasis. J. Clin. Apheresis, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jca.20290","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T16:49:36Z","timestamp":1305305376000},"page":"181-185","source":"Crossref","is-referenced-by-count":39,"title":["Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia"],"prefix":"10.1002","volume":"26","author":[{"given":"Gil Cunha","family":"De Santis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Correa Oliveira","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Gabriel Maltoni","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Benedito de Pina","family":"Almeida 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