{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:46:24Z","timestamp":1757540784667},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Red blood cell exchange (RBCEx) is frequently used in the management of patients with sickle cell disease (SCD) and acute chest syndrome or stroke, or to maintain target hemoglobin S (HbS) levels. In these settings, RBCEx is a category I or II recommendation according to guidelines on the use of therapeutic apheresis published by the American Society for Apheresis. Matching donor red blood cells (RBCs) to recipient phenotypes (e.g., C, E, K\u2010antigen negative) can decrease the risk of alloimmunization in patients with multi\u2010transfused SCD. However, this may select for donors with a higher prevalence of RBC disorders for which screening is not performed. This report describes a patient with SCD treated with RBCEx using five units negative for C, E, K, Fya, Fyb (prospectively matched), four of which were from donors with hemoglobin variants and\/or glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency. Pre\u2010RBCEx HbS quantification by high performance liquid chromatography (HPLC) demonstrated 49.3% HbS and 2.8% hemoglobin C, presumably from transfusion of a hemoglobin C\u2010containing RBC unit during a previous RBCEx. Post\u2010RBCEx HPLC showed the appearance of hemoglobin G\u2010Philadelphia. Two units were G6PD\u2010deficient. The patient did well, but the consequences of transfusing RBC units that are G6PD\u2010deficient and contain hemoglobin variants are unknown. Additional studies are needed to investigate effects on storage, in\u2010vivo RBC recovery and survival, and physiological effects following transfusion of these units. Post\u2010RBCEx HPLC can monitor RBCEx efficiency and detect the presence of abnormal transfused units. J. Clin. Apheresis 28:325\u2013329, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21255","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T00:29:50Z","timestamp":1362184190000},"page":"325-329","source":"Crossref","is-referenced-by-count":12,"title":["Acquired hemoglobin variants and exposure to glucose\u20106\u2010phosphate dehydrogenase deficient red blood cell units during exchange transfusion for sickle cell disease in a patient requiring antigen\u2010matched blood"],"prefix":"10.1002","volume":"28","author":[{"given":"Patricia M.","family":"Raciti","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center\u2010NewYork\u2010Presbyterian Hospital New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard O.","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center\u2010NewYork\u2010Presbyterian Hospital New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice F.","family":"Spitalnik","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center\u2010NewYork\u2010Presbyterian Hospital New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center\u2010NewYork\u2010Presbyterian Hospital New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Jhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center\u2010NewYork\u2010Presbyterian Hospital New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20240"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.21307\/immunohematology-2019-234","article-title":"Sickle cell disease: a review","volume":"25","author":"Roseff SD","year":"2009","journal-title":"Immunohematology"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-190-PMODRB"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34794330008.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.5858\/2006-130-1830-BTLTAH","article-title":"Blood transfusions leading to apparent hemoglobin C, S, and O\u2010Arab hemoglobinopathies","volume":"130","author":"Kozarski TB","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.5858\/1999-123-0642-BTAHC","article-title":"Blood transfusion\u2010acquired hemoglobin C","volume":"123","author":"Suarez AA","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01840.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03405.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(97)00009-X"},{"key":"e_1_2_5_11_1","first-page":"565","article-title":"Hemoglobin C acquired via a blood transfusion. 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