{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:40:20Z","timestamp":1775616020274,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>We report two patients with drug\u2010induced liver injury (DILI)\u2010related acute liver failure (ALF) who were successfully treated with high\u2010volume plasma exchange without liver transplantation. The first patient was a 66\u2010year\u2010old man admitted because of a perforated duodenal ulcer complicated with peritonitis and septic shock. After treatment with multiple antibiotics, the patient developed DILI and ALF. Grade 3 hepatic encephalopathy and profound jaundice were present. Symptoms and signs of ALF improved dramatically after initiation of plasma exchange. The patient was discharged uneventfully. The second patient was a 94\u2010year\u2010old man admitted for treatment of newly diagnosed pulmonary tuberculosis. DILI and ALF developed 5 days after initiation of anti\u2010tuberculosis treatment. Grade 4 hepatic encephalopathy was present. After plasma exchange, the patient's level of consciousness improved dramatically, and he recovered from ALF. These 2 cases show the potential of plasma exchange in the treatment of DILI despite occurrence acute liver failure. J. Clin. Apheresis, 28:430\u2013434, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21291","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T06:19:36Z","timestamp":1375856376000},"page":"430-434","source":"Crossref","is-referenced-by-count":21,"title":["Successful treatment of drug\u2010induced acute liver failure with high\u2010volume plasma exchange"],"prefix":"10.1002","volume":"28","author":[{"given":"Chung\u2010Te","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Wan Fang Hospital, Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tso\u2010Hsiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Wan Fang Hospital, Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Wan Fang Hospital, Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-12-200212170-00007"},{"key":"e_1_2_4_3_1","first-page":"2065","article-title":"Drug\u2010induced acute liver failure: results of a U.S","volume":"52","author":"Reuben A","year":"2010","journal-title":"multicenter, prospective study. 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