{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:03:33Z","timestamp":1762506213380},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p><jats:bold>Introduction<\/jats:bold>: Amiodarone is associated with thyroid dysfunction and life\u2010threatening thyrotoxicosis. In medically refractory cases, or where medical therapy is contraindicated, thyroidectomy may be required. To decrease perioperative thyroid storm and to reduce overall surgical risk, apheresis may be considered preoperatively to restore euthyroidism. <jats:bold>Case Description<\/jats:bold>: We report a 46\u2010year\u2010old female with a history of cardiac arrhythmia and tachycardia\u2010induced cardiomyopathy for which she received amiodarone. Months after discontinuation of amiodarone, the patient presented with wide complex tachycardia and symptoms of thyrotoxicosis. Laboratory testing confirmed severe thyrotoxicosis which was subsequently refractory to medical therapy. Total thyroidectomy was required. Following a total of 10 apheresis treatments, thyroid hormone levels were reduced to near normal levels and the patient's symptoms improved. Thyroidectomy was performed without intraoperative or postoperative complication. <jats:bold>Discussion<\/jats:bold>: In the setting of life\u2010threatening, medically refractory amiodarone\u2010induced thyrotoxicosis, therapeutic apheresis can effectively reduce thyroid hormone levels and restore a state of clinical and biochemical euthyroidism. J. Clin. Apheresis 29:168\u2013170, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21309","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T06:18:44Z","timestamp":1385101124000},"page":"168-170","source":"Crossref","is-referenced-by-count":13,"title":["Preoperative therapeutic apheresis for severe medically refractory amiodarone\u2010induced thyrotoxicosis: A case report"],"prefix":"10.1002","volume":"29","author":[{"given":"Jennifer","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanifa","family":"Dostmohamed","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isanne","family":"Schacter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Ariano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy St. Boniface General Hospital Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald S.","family":"Houston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Manitoba Winnipeg Manitoba Canada"},{"name":"Department of Haematology and Medical Oncology CancerCare Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Lewis","sequence":"additional","affiliation":[{"name":"Health Sciences Centre Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Knoll","sequence":"additional","affiliation":[{"name":"Health Sciences Centre Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Zarychanski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Manitoba Winnipeg Manitoba Canada"},{"name":"Department of Haematology and Medical Oncology CancerCare Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-1-28"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0180"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7599-6"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14073-1"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108053"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20200"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60782-4"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.04.010"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0903.2004.00600.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-1-199907060-00023"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:50:22Z","timestamp":1696391422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,22]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/jca.21309"],"URL":"https:\/\/doi.org\/10.1002\/jca.21309","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,22]]}}}