{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:12:06Z","timestamp":1772259126633,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,26]],"date-time":"2014-04-26T00:00:00Z","timestamp":1398470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>While extensive data demonstrated that plerixafor improves stem cell harvest in difficult\u2010to\u2010mobilize patients, economic concerns limit a broader application. We retrospectively assessed the effect of an early plerixafor rescue regimen for mobilization in patients with multiple myeloma. Patients were intended for high\u2010dose chemotherapy followed by autologous peripheral blood stem cell transplantation (ABSCT) and therefore received cyclophosphamide\u2010based mobilization chemotherapy and consecutive stimulation with granulocyte colony\u2010stimulating factor (G\u2010CSF). Fifteen patients with poor stem cell harvest in the first leukapheresis session received plerixafor. Data were compared with a matched historic control group of 45 patients who also had a poor stem cell yield in the first apheresis session, but continued mobilization with G\u2010CSF alone. Patients in the plerixafor group collected significantly more CD34+ cells in total (median 4.9 vs. 3.7 [range 1.6\u201314.1 vs. 1.1\u20138.0] \u00d7 10<jats:sup>6<\/jats:sup> CD34+ cells \/kg bw; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and also more CD34+ cells per leukapheresis procedure (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Consequently, they required a significantly lower number of leukapheresis procedures to achieve the collection goal (median 2.0 vs. 4.0 [range 2\u20133 vs. 2\u20139] procedures; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The efficiency of the collected stem cells in terms of hematologic engraftment after ABSCT was found to be equal in both groups. These data demonstrate that rescue mobilization with plerixafor triggered by a low stem cell yield in the first leukapheresis session is effective. Although the actual economic benefit may vary depending on the local leukapheresis costs, the median saving of two leukapheresis procedures offsets most of the expenses for the substance in this setting. An exemplary cost calculation is provided to illustrate this effect. J. Clin. Apheresis 29:299\u2013304 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21323","type":"journal-article","created":{"date-parts":[[2014,4,26]],"date-time":"2014-04-26T06:13:12Z","timestamp":1398492792000},"page":"299-304","source":"Crossref","is-referenced-by-count":35,"title":["Rescue stem cell mobilization with plerixafor economizes leukapheresis in patients with multiple myeloma"],"prefix":"10.1002","volume":"29","author":[{"given":"Michael","family":"Hundemer","sequence":"first","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bruckner","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Kraeker","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Neben","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Witzens\u2010Harig","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"},{"name":"National Center for Tumor Diseases Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Wuchter","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University Heidelberg 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