{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:10:31Z","timestamp":1696482631596},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>ICE\/R\u2010ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory\/relapsed lymphoma. Few studies have addressed which factors are important in determining peripheral blood stem cell (PBSC) mobilization efficiency or nonmobilization following ICE\/R\u2010ICE. Between 2004 and 2013, 88 patients with refractory\/relapsed lymphoma who received ICE\/R\u2010ICE salvage\u2010chemotherapy prior to granulocyte colony stimulating factor (G\u2010CSF) stimulated PBSC mobilization at a single center were identified. Mobilization efficiency was assessed by time from ICE\/R\u2010ICE to day of harvest, duration of G\u2010CSF use, days to peripheral blood (PB) CD34<jats:sup>+<\/jats:sup> \u226515\/\u00b5L, PB CD34<jats:sup>+<\/jats:sup> number on harvest day, CD34<jats:sup>+<\/jats:sup> yield and nonmobilization rate. Median PB CD34<jats:sup>+<\/jats:sup> at harvest were 54\/\u03bcL (7\u2013524); median days to first apheresis was 15 (11\u201330); median harvested total CD34<jats:sup>+<\/jats:sup> were 5.46 \u00d7 10<jats:sup>6<\/jats:sup>\/kg (0.96\u201344.36); 71 patients (80.7%) successfully mobilized; 20 (22.7%) patients were poor mobilizers; 14 (15.9%) patients were considered nonmobilizers with maximal PB CD34<jats:sup>+<\/jats:sup> &lt;7\/\u00b5L and did not proceed to apheresis. Six of 20 poor mobilizers were apheresed with PB CD34<jats:sup>+<\/jats:sup> 7\u201312\/\u00b5L, 50% were successfully harvested. No differences were found between ICE and R\u2010ICE regimens. Impaired mobilization efficiency was associated with age, remission status, &gt;1 line of induction chemotherapy, four cycles ICE\/R\u2010ICE and grade 4 neutropenia. Prior bone marrow (BM) involvement was associated with nonmobilization. The majority of patients can be successfully mobilized with ICE\/R\u2010ICE. Prior BM involvement is associated with high rates of nonmobilization following ICE\/R\u2010ICE. Such patients may benefit from novel mobilization agents and\/or alternative salvage regimens to ICE\/R\u2010ICE. J. Clin. Apheresis 29:322\u2013330 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21340","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T05:09:00Z","timestamp":1403154540000},"page":"322-330","source":"Crossref","is-referenced-by-count":6,"title":["Factors determining pbsc mobilization efficiency and nonmobilization following ICE with or without rituximab (R\u2010ICE) salvage therapy for refractory or relapsed lymphoma prior to autologous transplantation"],"prefix":"10.1002","volume":"29","author":[{"given":"Wei","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Haematology and Transfusion Medicine Royal North Shore Hospital Sydney Australia"},{"name":"Northern Blood Research Centre, Kolling Institute of Medical Research, University of Sydney Sydney Australia"},{"name":"Haematology Laboratory, PaLMs, Royal North Shore Hospital Sydney 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