{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:13:37Z","timestamp":1794255217542,"version":"4.9.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Transplant\u2010associated thrombotic microangiopathy (TA\u2010TMA) is a rare clinical syndrome associated with significant mortality. Although the use of plasma exchange (PE) in TA\u2010TMA continues to be explored, evidence for its efficacy is debated. We performed a single institution, retrospective study to evaluate the efficacy of PE in treating TA\u2010TMA patients. Special attention was given to efficacy in relation to the timing of presentation with TA\u2010TMA since transplant. Thirty\u2010three patients diagnosed with TA\u2010TMA and treated with PE between January 1999 and December 2010 were included in the study. Clinical improvement was seen in eight patients (24%); four patients achieved complete resolution while the remaining four achieved partial resolution. All\u2010cause day\u201030 and day\u2010100 mortality was 33 and 55%, respectively. There was a trend toward a better outcome (complete\/partial) for those presenting\u2009\u2265\u2009100 days after transplantation (42%) vs.\u2009&lt;\u2009100 days after transplantation (14%; <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20090.15). Similarly, those presenting at\u2009\u2265\u2009100 days had better, but not significantly, 30\u2010day and 100\u2010day all\u2010cause mortality rates (17 and 33%, respectively) than those presenting at\u2009&lt;\u2009100 days (43 and 67%, respectively) (<jats:italic>P<\/jats:italic>\u2010value\u2009=\u20090.25 and 0.08, for 30\u2010 and 100\u2010day all\u2010cause mortality, respectively). This is the first study looking at the efficacy of PE while considering the time of presentation since transplantation and is one of the largest single institution series of TA\u2010TMA. The overall efficacy of PE is poor; however, patients who present with TA\u2010TMA \u2265100 days after transplant may have better outcome and lower mortality. J. Clin. Apheresis 30:147\u2013153, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21352","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T06:59:48Z","timestamp":1410937188000},"page":"147-153","source":"Crossref","is-referenced-by-count":24,"title":["Outcomes of plasma exchange in patients with transplant\u2010associated thrombotic microangiopathy based on time of presentation since transplant"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-1043","authenticated-orcid":false,"given":"Sudhanshu","family":"Mulay","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology University of Connecticut School of Medicine Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin D.","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra C.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Winters","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Gastineau","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"},{"name":"Division of Hematology Mayo Clinic Rochester 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